Transient Elastography for the Prediction of Oxaliplatin-Associated Liver Injury in Colon Cancer Patients : A Preliminary Analysis

Abstract

Elastography is a good tool for evaluating hepatic injury after FOLFOX treatment.

Role of Virtual Touch Tissue Imaging Quantification in the Assessment of Hepatic Sinusoidal Obstruction Syndrome in a Rat Model

“…As shown by the results of our multivariable analysis, the liver SWV was positively correlated with the histologic score. These findings indicate the potential role of VTIQ for the diagnosis, assessment, and longitudinal follow‐up of HSOS, which align with the findings of previous research on other elastographic techniques, such as transient elastography, SWE, and acoustic radiation force impulse elastography …”

“…These findings indicate the potential role of VTIQ for the diagnosis, assessment, and longitudinal follow-up of HSOS, which align with the findings of previous research on other elastographic techniques, such as transient elastography, SWE, and acoustic radiation force impulse elastography. [9][10][11]19 Conventional US showed ascites, hepatomegaly, and homogeneous or inhomogeneous parenchymal hypoechogenicity in our study. These features may be explained by sinusoidal obstruction or veno-occlusion due to sinusoid damage and venular narrowing.…”

Splenomegaly in FOLFOX-naïve stage IV or recurrent colorectal cancer patients due to chemotherapy-associated hepatotoxicity can be predicted by the aspartate aminotransferase to platelet ratio before chemotherapy

“…We previously reported that an indocyanine green retention test, the AST level before hepatectomy, and the administration of 6 cycles or more of FOLFOX were able to predict the presence of histopathological sinusoidal obstruction syndrome [13]. Oki et al [23] used elastography (Fibroscan TM ) to show that the stiffness of the liver was increased after chemotherapy within 48 h, and that the hepatic stiffness was normalized in most cases within 2 weeks after treatment. However, the hepatic stiffness gradually increased after repeated FOLFOX4 in some cases.…”

Evaluation and management of hepatic injury induced by oxaliplatin‐based chemotherapy in patients with hepatic resection for colorectal liver metastasis

“…Some investigators explored several parameters to evaluate and predict the SOS state of the liver after chemotherapy (Table ) . As a potential consequence of SOS, sinusoidal injury associated with L‐OHP increased resistance to blood flow between the portal and hepatic venous systems.…”

“…Some investigators explored several parameters to evaluate and predict the SOS state of the liver after chemotherapy (Table 3). 32,[40][41][42][43][44][45][46][47][48] As a potential consequence of SOS, sinusoidal injury associated with L-OHP increased resistance to blood flow between the portal and hepatic venous systems. Then, portal hypertension developed splenomegaly, persistent thrombocytopenia, and bleeding of esophageal and hemorrhoidal varices.…”