Transient exposure to environmental estrogen affects embryonic development of brown trout (Salmo trutta fario)

Schubert, Sara; Peter, Armin; Schönenberger, René; Suter, Marc J.‐F.; Segner, Helmut; Burkhardt‐Holm, Patricia

doi:10.1016/j.aquatox.2014.10.007

Cited by 11 publications

(10 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other microcontaminants could have affected the time to hatch through different mechanisms. For instance, it has been shown that exposure of early life stages of salmonids to steroidal estrogens can alter time to hatch (Marlatt et al ; Schubert et al ).…”

Section: Resultsmentioning

confidence: 99%

Toxicity of extracts from municipal wastewater to early life stages of Japanese medaka (Oryzias latipes) to evaluate removals of micropollutants by wastewater treatment

Maya¹,

Crispo²,

McFarland³

et al. 2017

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Treatment of municipal wastewater reduces the concentrations of some pharmaceuticals and personal care products (PPCPs), hormones, and drugs of abuse. However, reduced concentrations of these micropollutants in wastewater may not correlate with reduced toxicity because transformations of micropollutants and/or the formation of disinfection byproducts may generate toxic compounds. In the present study, we prepared extracts by solid phase extraction of samples collected from wastewater treatment plants (WWTPs) at various stages of treatment and tested these extracts for toxicity to early life stages of Japanese medaka (Oryzias latipes). Toxicity data for extracts prepared from a WWTP with secondary treatment showed that the numbers of exposed embryos (n ¼ 12 per treatment) that did not hatch increased from 1 of 12 for the treatment with untreated effluent to 5 of 12 for the treatment with final treated effluent. For extracts prepared from a WWTP with tertiary treatment, toxicity among exposed embryos (n ¼ 12 per treatment) also increased with each step of wastewater treatment, as shown by mortalities of 2 of 12 and 8 of 12 in treatments with extracts from untreated and final treated effluent, respectively, as well as an increase in the numbers of embryos that did not hatch from 2 of 12 to 9 of 12 in treatments with untreated and final treated effluent, respectively. Ozonation of treated wastewater collected from a third WWTP caused a high incidence of delayed hatch in exposed embryos (n ¼ 24 per treatment). However, hatching success and the numbers of developmental abnormalities in embryos from this ozonation treatment were not different from controls. The present study shows the value of including toxicity testing to assess the effectiveness of technologies for treatment of municipal wastewater. Environ Toxicol Chem 2018;37:136-144. C 2017 SETAC

show abstract

Section: Resultsmentioning

confidence: 99%

Toxicity of extracts from municipal wastewater to early life stages of Japanese medaka (Oryzias latipes) to evaluate removals of micropollutants by wastewater treatment

Maya¹,

Crispo²,

McFarland³

et al. 2017

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

show abstract

“…Schubert et al [33] examined the sensitivity of brown trout embryos (Salmo trutta fario L.) to "environmentally relevant concentrations" of E2 in the time between fertilisation and hatch (70 days). They exposed the fish embryos to transient E2 concentrations of 3.8 and 38.0 ng/l E2 for 2 h. Four scenarios were investigated: exposure (a) directly after fertilisation, (b) at "eyeing stage", (c) weekly until hatch, and (d) bi-weekly until hatch.…”

Section: Discussionmentioning

confidence: 99%

Estrogenic activity in drainage water: a field study on a Swiss cattle pasture

2015

View full text Add to dashboard Cite

Background: Dairy cow manure applied to pastures is a significant potential source of estrogenic contamination in nearby streams. One possible pathway is through infiltration via preferential flow to drainage pipes, particularly after heavy rainfall events. In a period of 73 days in the spring of 2010, a drainage catchment in a cattle pasture in the Swiss lowlands was closely monitored. Manure was applied three times during the study, and part of the catchment was also subjected to grazing. During five field campaigns, water samples from two sampling locations were taken for 4-24 h in consecutive sampling intervals. 17β-estradiol equivalents (EEQ) were determined with the yeast estrogen screen (YES) and the ER-CALUX assay. Some water chemistry parameters, pH, conductivity, oxygen content and soil moisture tension were also monitored. Results: Washout of estrogenic activity was highest during or right after heavy rainfall events, shortly after manure spreading, when peak values of >10 ng/l EEQ were found in several samples. However, in two field campaigns, high EEQ values were also found 14 and 28 days, after the last manure application, in one case during a dry weather period. This indicates that estrogenic compounds are more stable in natural soils than what is expected from data gathered in lab studies. Conclusions: Streams in agricultural areas with a high proportion of drained land may be subject to numerous peaks of EEQ during the course of the year. This may have a negative effect on aquatic organisms, namely fish embryos, living in these streams.

show abstract

“…For example, a whole inland lake study of the synthetic estrogen 17α-ethynyloestradiol in Ontario, Canada, determined that small-bodied fishes were most affected, and that indirect effects cascaded through the aquatic food web affecting the top predator (Lake Trout Salvelinus namaycush), as well as zooplankton (Kidd et al 2014). The long list of pharmaceutical effects on fishes includes changes in time spent swimming versus in refuge (Brandao et al 2013), embryonic development (Schubert et al 2014), gene expression (Gunnarsson et al 2009;Jeffries et al 2015), and feeding (Brodin et al 2013;Hedgespeth et al 2014), as well as metabolic disruption (Meador et al 2018), reproductive failure (Nash et al 2004), population collapse (Kidd et al 2007), and change in assemblage structure (Sanchez et al 2011).…”

Section: Box 1 Pharmaceuticalsmentioning

confidence: 99%