Transient fluid flow improves photoimmunoconjugate delivery and photoimmunotherapy efficacy

Sorrin, Aaron J.; Zhou, Keri; May, K. N.; Liu, Cindy H.; McNaughton, Kathryn; Rahman, Idrisa; Liang, Barry J.; Rizvi, Imran; Roque, Dana M.; Huang, Huang‐Chiao

doi:10.1016/j.isci.2023.107221

Cited by 4 publications

(1 citation statement)

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“…One targeting strategy involves the synthesis of FA-photosensitizer conjugates for FA receptor-mediated PDT [24]. To improve the specificity and drug accumulation approaches like photoimmunotherapy, which involves the delivery of PS through conjugation to an antibody, have also been explored as a therapeutic for cancer [25]. In this study, we demonstrate the use of a combination approach comprising both chemotherapy and phototherapy, referred to as chemophototherapy (CPT).…”

Section: Introductionmentioning

confidence: 99%

Folate-Targeted Nanoliposomal Chemophototherapy

Chitgupi,

Qin,

Ghosh

et al. 2023

Pharmaceutics

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Light-responsive liposomes have been developed for the on-demand release of drugs. However, efficient delivery of chemotherapeutic drugs to tumor for cancer theranostics remains a challenge. Herein, folic acid (FA), an established ligand for targeted drug delivery, was used to decorate light-sensitive porphyrin-phospholipid (PoP) liposomes, which were assessed for FA-targeted chemophototherapy (CPT). PoP liposomes and FA-conjugated PoP liposomes were loaded with Doxorubicin (Dox), and physical properties were characterized. In vitro, FA-PoP liposomes that were incubated with FA receptor-overexpressing human KB cancer cells showed increased uptake compared to non-targeted PoP liposomes. Dox and PoP contributed towards chemophototherapy (CPT) in vitro, and PoP and FA-PoP liposomes induced cell killing. In vivo, mice bearing subcutaneous KB tumors treated with PoP or FA-PoP liposomes loaded with Dox, followed by 665 nm laser treatment, had delayed tumor growth and improved survival. Dox delivery to tumors increased following laser irradiation for both PoP and FA-PoP liposomes. Thus, while Dox-FA-PoP liposomes were effective following systemic administration and local light irradiation in this tumor model, the FA targeting moiety did not appear essential for anti-tumor responses.

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Section: Introductionmentioning

confidence: 99%