Transient Gestational Diabetes Insipidus

Abstract

Our objective is to present a rare case of gestational diabetes insipidus (GDI) and review the literature to increase awareness. We describe a case of gestational diabetes insipidus, outline the details of the endocrine investigations, and discuss management.A 25-year-old woman, postcaesarian section, presented with polyuria, polydipsia, nausea, headache, loss of appetite, and occasional vomiting for 4 weeks. Physical examination, laboratory and radiographic findings were consistent with diabetes insipidus. She responded to removal of the placenta, desmopressin therapy, and appropriate fluid management. Literature review indicates GDI is rare. The precise pathophysiologic mechanism is uncertain.Clinicians should be aware of GDI to make an early diagnosis and initiate appropriate management. The main steps of the management include the removal of the placenta, the use of desmopressin, and close monitoring of fluid and electrolyte balance.