Transient global amnesia: The cerebral Takotsubo?

Finsterer, Josef; Stöllberger, Claudia

doi:10.1016/j.jns.2017.03.041

Cited by 18 publications

(12 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Risk factors for developing a TGA may be a migraine history, cardiovascular risk factors, and emotional stress. Since TGA may be associated with TTS in single cases (Table 1) [1–5], it has been recently proposed that TGA could also be due to a catecholamine storm and could represent the cerebral form of a TTS [2]. However, none of these speculations has been proven to consistently explain the common occurrence of TGA and TTS [9].…”

Section: Discussionmentioning

confidence: 99%

Simultaneous transient global amnesia and Takotsubo syndrome after death of a relative: a case report

Finsterer

Stöllberger

2019

J Med Case Reports

Self Cite

View full text Add to dashboard Cite

IntroductionSimultaneous occurrence of transient global amnesia and Takotsubo syndrome has been only rarely reported. Here we report another patient with a transient global amnesia and concomitant Takotsubo syndrome.Case presentationOur patient is a 64-year-old white man with a previous history of myocarditis from borreliosis who developed sudden-onset confusional state with perseverations and repetition of the same questions during a funeral for his brother-in-law. Upon neurological work-up and after spontaneous resolution of most of the neurological deficits, transient global amnesia was diagnosed. Blood tests revealed moderate renal insufficiency, elevated troponin-T, and elevated N-terminal prohormone of brain natriuretic peptide. Electrocardiography showed left anterior hemiblock and negative T-waves in V2–V6. Upon transthoracic echocardiography the apical type of a Takotsubo syndrome was suspected. Since coronary angiography was normal and electrocardiography and echocardiographic abnormalities resolved under candesartan, bisoprolol, acetyl-salicylic acid, and atorvastatin within a few days after onset, Takotsubo syndrome was diagnosed.ConclusionsSince Takotsubo syndrome may be associated with transient global amnesia a causal relation may exist. A possible trigger for both conditions could be severe emotional stress from the loss of a close relative. A possible common pathomechanism could be overstimulation of adrenergic receptors in the myocardium, the cerebrum, or the coronary or cerebral arteries. Whether pre-existing myocardial compromise promotes the development of Takotsubo syndrome requires further investigations.

show abstract

Section: Discussionmentioning

confidence: 99%

Simultaneous transient global amnesia and Takotsubo syndrome after death of a relative: a case report

Finsterer

Stöllberger

2019

J Med Case Reports

Self Cite

View full text Add to dashboard Cite

show abstract

“…We hypothesize that posterior inferior cerebellar artery, posterior cerebral arteries, and lenticulostriate arteries are selectively prone to transient vasospasm due to the high adrenergic state from increased circulating catecholamines affecting their autoregulation. Hippocampi are involved in other disorders such as transient global amnesia and one of the proposed mechanism is due to increased sympathetic activity causing anterograde amnesia and neuroimaging evidence of punctate hippocampal lesions [ 18 ]. Cocaine might affect the hippocampi in a similar way by causing transient high catecholaminergic state.…”

Section: Discussionmentioning

confidence: 99%

Cocaine Induced Bilateral Posterior Inferior Cerebellar Artery and Hippocampal Infarction

Mullaguri

Battineni

Narayan

et al. 2018

Cureus

View full text Add to dashboard Cite

Cocaine is one of the most commonly abused recreational drugs, second only to marijuana. It blocks the reuptake of neurotransmitters such as norepinephrine and dopamine, that leads to persistent post-synaptic stimulation responsible for its excitatory effects. Cocaine-related strokes, both ischemic and hemorrhagic, have been well described in the literature and cerebral vasospasm is hypothesized as one of the major mechanisms responsible for the presentation. Although cases of posterior circulation infarction were previously reported, we herein report a rare presentation of a cocaine-induced bilateral posterior inferior cerebellar artery and hippocampal infarction in a middle-aged female.

show abstract

“…[ 33 ] Some authors believe that stress-induced catecholamine release may lead to hypoxia or ischemia, whereas others believe that the neurotransmitters involved may affect the formation of memory. [ 34 – 39 ] Severe emotional reactions may contribute to the destabilization of the CA1 sector of the hippocampus via massive glutamate release. [ 40 ] However, it has been shown that psychogenic amnesia can be linked to several psychiatric disorders including post-traumatic stress disorder and dissociative disorders, where the loss of memory could be considered a defensive psychological mechanism, often associated to a phobic personality trait.…”

Section: Discussionmentioning

confidence: 99%

Risk factors of transient global amnesia

et al. 2018

View full text Add to dashboard Cite

Introduction:Transient global amnesia (TGA) is characterized by a sudden onset of anterograde and retrograde amnesia, sometimes associated with mild subclinical neuropsychological deficits and vegetative symptoms, lasting for days after the episode. Migraine history, cardiovascular risk factors, and emotional stress are considered possible risk factors. TGA usually occurs during the seventh decade of life, that is, when risk factors and concomitant pathologies have a higher incidence.Case Presentation:We report 3 cases of TGA triggered by different causes (cardiovascular risk factors, emotional stress, and orgasm) with an unusual young onset (patient 1 was a 40-year-old woman, patient 2 was a 21-year-old woman, and patient 3 a 32-year-old man). The patients underwent neuroimaging and cardiovascular examination, and neuropsychological evaluation, without important abnormalities. TGA completely recovery within 1 to 7 days.Conclusions:The occurrence of different precipitating events and accurate questioning (in the absence of head trauma) seem to be key features in making the diagnosis of TGA, besides a complete neuropsychiatric and cardiovascular assessment.

show abstract

Transient global amnesia: The cerebral Takotsubo?

Cited by 18 publications

References 7 publications

Simultaneous transient global amnesia and Takotsubo syndrome after death of a relative: a case report

Simultaneous transient global amnesia and Takotsubo syndrome after death of a relative: a case report

Cocaine Induced Bilateral Posterior Inferior Cerebellar Artery and Hippocampal Infarction

Risk factors of transient global amnesia

Contact Info

Product

Resources

About