Transient Hearing Loss in Adults Associated With Zika Virus Infection

Vinhaes, Eriko Soares de Azevedo; Santos, Luciane Amorim; Dias, Lislane; Andrade, Nilvano Alves de; Bezerra, Victor Hugo Braz; Carvalho, Anderson T. de; Moraes, Laíse de; Henriques, Daniele Freitas; Azar, Sasha R.; Vasilakis, Nikos; Ko, Albert Icksang; Andrade, Bruno B.; Siqueira, Isadora Cristina de; Khouri, Ricardo; Boaventura, Viviane

doi:10.1093/cid/ciw770

Cited by 26 publications

(37 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… 10 , 11 , 12 , 13 Enzyme-linked immunosorbent assays (ELISAs) were performed to detect IgM antibodies against DENV, ZIKV and CHIKV in paired sera and CSF. 14 , 15 For the differential diagnosis, CSF samples from patients with CNS damage (encephalitis, ATM and ADEM) were tested by polymerase chain reaction (PCR) for herpesviruses and by reverse transcription polymerase chain reaction (RT-PCR) for enteroviruses. 16 , 17 For GBS cases, serum samples were also tested for Campylobacter jejuni IgM antibodies by ELISA (Serion ELISA Classic, Institute Virion/Serion, Wurzburg, Germany).…”

Section: Methodsmentioning

confidence: 99%

Potential role of dengue virus, chikungunya virus and Zika virus in neurological diseases

Vieira

Costa

Linhares

et al. 2018

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

This study showed that laboratory markers of recent infection by dengue, Zika or chikungunya arboviruses were detected in the biological samples of approximately one-third of patients with encephalitis, myelitis, encephalomyelitis or Guillain-Barré syndrome, in a surveillance programme in Piauí state, Brazil, between 2015-2016. Fever and myalgia had been associated with these cases. Since in non-tropical countries most infections or parainfectious diseases associated with the nervous system are attributed to herpesviruses, enteroviruses, and Campylobacter jejuni, the present findings indicate that in tropical countries, arboviruses may now play a more important role and reinforce the need for their surveillance and systematic investigation in the tropics.

show abstract

Section: Methodsmentioning

confidence: 99%

Potential role of dengue virus, chikungunya virus and Zika virus in neurological diseases

Vieira

Costa

Linhares

et al. 2018

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

show abstract

“…However, in recent years, more serious complications such as microcephaly malformations in newborns and Guillain–Barré syndrome in adults have been reported in ZIKV-infected individual. Furthermore, some unusual clinical signs such as transient hearing loss, vomiting, retinal lesions, severe abdominal pain and cardiovascular complications were also observed in patients with ZIKV infection 7 – 10 .…”

Section: Introductionmentioning

confidence: 97%

A unique case of human Zika virus infection in association with severe liver injury and coagulation disorders

Cui

et al. 2017

Sci Rep

View full text Add to dashboard Cite

AbsatrctZika virus (ZIKV) has caused major concern globally due to its rapid dissemination and close association with microcephaly in children and Gullian-Barr syndrome in adults. In this study, we identified a patient returned from Cambodia who experienced high fever, chill and myalgia. Lab tests discovered sign of severe liver injury including significantly elevated serum transaminases’ level, decreased serum albumin level, and markedly increased levels of lactic dehydrogenase, alpha-hydroxybutyric dehydrogenase and creatine kinase in serum. Moreover, severe thrombocytopenia and altered blood levels of fibrinogen and fibrinogen degradation product were also observed, indicating the existence of clotting disorders. A ZIKV strain clustered into the Asian lineage was isolated from the patient’s serum. When inoculated into suckling mice, this virus significantly retarded mouse body-weight gain and caused 70% mortality. Our results demonstrate a close association between ZIKV and severe liver injury and coagulation disorders and suggest that clinicians should be aware of compatible symptoms in patients and manage them accordingly.

show abstract

“…Across studies, 56 (21.2%) of 264 individuals were found to have some degree of HL. 18,[22][23][24][25][26][27][28][29][30][31][32][33][34] Four of the fourteen articles described acquired HL in adults following Zika infection ( Table 1). The HL in these cases varied from moderate to severe and was reported as both unilateral and bilateral, with most patients experiencing recovery to normal or previous thresholds.…”

Section: Resultsmentioning

confidence: 99%

“…The HL in these cases varied from moderate to severe and was reported as both unilateral and bilateral, with most patients experiencing recovery to normal or previous thresholds. [22][23][24]30 Ten articles presented complication data of congenital Zika syndrome related to HL (Table 1). 18,22,[25][26][27][28][29][33][34][35] The majority of these studies used standard HL screening methods for infants, including measurement of auditory brainstem response and otoacoustic emission, which assesses cochlear function.…”

Section: Resultsmentioning

confidence: 99%

A Review of Hearing Loss Associated with Zika, Ebola, and Lassa Fever

Ficenec

Schieffelin

Emmett

2019

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

The neglected tropical diseases Zika, Ebola, and Lassa fever (LF) have all been noted to cause some degree of hearing loss (HL). Hearing loss is a chronic disability that can lead to a variety of detrimental effects, including speech and language delays in children, decreased economic productivity in adults, and accelerated cognitive decline in older adults. The objective of this review is to summarize what is known regarding HL secondary to these viruses. Literature for this review was gathered using the PubMed database. Articles were excluded if there were no data of the respective viruses, postinfectious complications, or conditions related to survivorship. A total of 50 articles were included in this review. Fourteen articles discussing Zika virus and subsequent complications were included. Across these studies, 56 (21.2%) of 264 Zika-infected individuals were found to have HL. Twenty-one articles discussing Ebola virus and subsequent complications were included, with 190 (5.7%) of 3,350 Ebola survivors found to have HL. Fifteen additional articles discussing LF and subsequent complications were included. Of 926 individuals with LF, 79 (8.5%) were found to have HL. These results demonstrate a relationship between HL and infection. The true prevalence is likely underestimated, however, because of lack of standardization of reporting and measurement. Future studies of viral sequelae would benefit from including audiometric evaluation. This information is critical to understanding pathophysiology, preventing future cases of this disability, and improving quality of life after survival of infection.

show abstract

Transient Hearing Loss in Adults Associated With Zika Virus Infection

Cited by 26 publications

References 12 publications

Potential role of dengue virus, chikungunya virus and Zika virus in neurological diseases

Potential role of dengue virus, chikungunya virus and Zika virus in neurological diseases

A unique case of human Zika virus infection in association with severe liver injury and coagulation disorders

A Review of Hearing Loss Associated with Zika, Ebola, and Lassa Fever

Contact Info

Product

Resources

About