Transient heat stress protects from severe endothelial damage and dysfunction during prolonged experimental ex-vivo lung perfusion
Roumen Parapanov,
Anne Debonneville,
Manon Allouche
et al.
Abstract:IntroductionThe pulmonary endothelium is the primary target of lung ischemia-reperfusion injury leading to primary graft dysfunction after lung transplantation. We hypothesized that treating damaged rat lungs by a transient heat stress during ex-vivo lung perfusion (EVLP) to elicit a pulmonary heat shock response could protect the endothelium from severe reperfusion injury.MethodsRat lungs damaged by 1h warm ischemia were reperfused on an EVLP platform for up to 6h at a constant temperature (T°) of 37°C (EVLP3… Show more
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