Transient Hypermetabolism of the Basal Ganglia Following Perinatal Hypoxia

Brain Perfusion Imaging in Neonates: An Overview

“…26 A recent study conducted on 60 infants, including 24 infants with HIE, 27 showed that cerebral glucose metabolism increased with gestational age and that the standardized uptake values were lower in infants with HIE than in healthy term infants, especially in the subcortical white matter, thalamus, and basal ganglia areas, and correlated with the degree of severity of HIE, except for the basal ganglia. Batista et al 28 suggested that there is a transient increase in glucose metabolism in the basal ganglia after perinatal hypoxia and that it may be associated with excess glutamatergic activity in the basal ganglia, leading to severe damage.…”

Sonographic Changes in Hypoxic-Ischaemic Encephalopathy

“…It is also possible that the requirement for energetic fuel is low because of the low metabolism in www.intechopen.com the damaged cells in the cases of severe brain damage. The only published case report, following longitudinal changes in cerebral metabolism in an infant with HIE and subsequent cerebral palsy, has demonstrated transient hypermetabolism in the neonatal period followed by severe hypometabolism later during childhood (Batista et al, 2007). More longitudinal data about cerebral blood flow and metabolism is needed to understand the causes of long term low cerebral blood flow velocities in infants with a severe HIE/poor prognosis months after birth asphyxia.…”

Sonographic Changes in Hypoxic-Ischaemic Encephalopathy

“…Such decreased brain volume probably no longer needs a normal blood flow. It is also possible that the requirement for energetic fuel is low because of the low metabolism in (Batista et al, 2007). More longitudinal data about cerebral blood flow and metabolism is needed to understand the causes of long term low cerebral blood flow velocities in infants with a severe HIE/poor prognosis months after birth asphyxia.…”