Transient hyperphosphatasaemia of infancy

Abstract

In five patients with benign transient hyperphosphatasaemia (THP), high activities of so-called "atypical" alkaline phosphatase or fragment isoenzymes were detected. One case occurred after rotavirus infection. Incubation with neuraminidase suggested that "atypical" alkaline phosphatase originated from highly glycosylated bone and liver isoenzymes. This may have been due to virus-induced low isoenzyme clearance from serum. The course of isoenzyme activities in THP following rotavirus infection was followed. Determination of atypical alkaline phosphatase may be useful in the diagnosis of THP.

Transient hyperphosphatasemia in children revisited

“…The length of abnormal ALP values and the benign outcome of our patients are similar to what is reported in the literature 3,4,6,10,11,14,17,21,29 . 2 years of age or younger, which is also consistent with the literature 5,7,10,11,13,16,19 …”

“…3,4,6,10,11,14,17,21,29 2 years of age or younger, which is also consistent with the literature. 5,7,10,11,13,16,19 The main limitation of the study is its retrospective nature which limited our ability to control the clinical investigation and ensure appropriate follow-up and timing of laboratory studies. Accordingly, there are not enough serial data of total ALP and ALP isoenzyme patterns.…”

“…Ninetyfive percent of the children were 2 years or younger. One hundred and twenty-two children served as controls (mean age16 1 8.4 months, P = 0.97). The patients were divided into four subgroups by their presenting symptoms.…”