Transient hypogammaglobulinaemia in newly diagnosed juvenile diabetes

Kanakoudi-Tsakalidis, F; Harsoulis, P.; Katzos, George; Dadaliari, M; Jn, McNally; Gf, Bottazzo

doi:10.1530/acta.0.107s0029

Cited by 3 publications

(4 citation statements)

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“…KanakoudiTsakalidis et al [12] found transient hypogammaglobulinaemia in the early stages of juvenile diabetes. Follow up study in these patients showed a gradual increase of IgG, IgA and IgM levels to normal approximately i year later.…”

Section: Discussionmentioning

confidence: 99%

“…IgG subclass deficiency has been also noted in connection with auto-immune diseases such as systemic lupus erythematous, and auto-immune cytopenias [4, 191 . Much evidence suggests that insulin-dependent diabetes mellitus (IDDM) is an auto-immune disease [2,7,8,10]. Conflicting abnormalities in immunoglobulin levels have been described in IDDM [9,11,12]. Follow up studies of Ig concentrations showed low levels of IgG, IgA, IgM at disease onset followed by a gradual normalization [12].…”

Section: Offprint Requests To: L Cortonamentioning

confidence: 99%

“…Conflicting abnormalities in immunoglobulin levels have been described in IDDM [9,11,12]. Follow up studies of Ig concentrations showed low levels of IgG, IgA, IgM at disease onset followed by a gradual normalization [12]. IgG subclasses imbalance [20,25] has also been described, however follow up studies have not been reported.…”

Section: Offprint Requests To: L Cortonamentioning

confidence: 99%

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Transient IgG subclass deficiencies in newly diagnosed diabetic children

Cortona

Avanzini

Martinetti³

et al. 1992

Eur J Pediatr

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In 27 children (15 males and 12 females) with insulin-dependent diabetes mellitus (IDDM), aged 1.2-13.5 years (mean 9.9 +/- 3.6 years) we investigated immunoglobulins (IgG, IgA, IgM), IgG subclass levels and islet-cell antibodies (ICA) at diagnosis and at 6 and 12 months after disease onset. At diagnosis, IgG levels were lower than -2SD in 7 patients (26%), IgA in 1 (3.7%), IgM in 1 (3.7%). IgG subclass levels were below the 3rd percentile in 13 patients (48.1%); in particular IgG1 in 7 (26%), IgG2 in 3 (11.1%), IgG3 in 2 and IgG4 undetectable in 1 case. In 3 out of the 13 patients combined IgG1-IgG3, IgG1-IgG2 and IgG1-IgG4-IgA deficiencies were observed. ICA were greater than 20 Juvenile Diabetes Foundation units in 17/27 patients. The HLA-DR2 frequency was higher in patients with IgG subclass deficiency than in patients with normal IgG subclass levels. During follow up, IgG levels normalized in 6 patients while IgA and IgM did not change. IgG1 normalized in 5 out of the 7 patients, IgG2 in all patients while IgG3 and IgG4 did not change. One year later ICA were still present in 8/27 patients. The hypogammaglobulinaemia and IgG subclass deficiencies observed in our patients could have either a genetic or an acquired basis.

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Section: Discussionmentioning

confidence: 99%

Section: Offprint Requests To: L Cortonamentioning

confidence: 99%

Section: Offprint Requests To: L Cortonamentioning

confidence: 99%

See 1 more Smart Citation

Transient IgG subclass deficiencies in newly diagnosed diabetic children

Cortona

Avanzini

Martinetti³

et al. 1992

Eur J Pediatr

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“…Some authors [16] have found that IDDM patients had serum IgA and IgM concentrations comparable to con trols, while IgG levels of patients were significantly low er. Kanakoudi-Tsakalidis et al [17] found transient hy pogammaglobulinemia in the early stages of juvenile dia betes. Follow-up study in their patients showed a gradual increase of IgG, IgA and IgM levels to normal approxi mately 1 year later.…”

Section: Discussionmentioning

confidence: 98%

Spontaneous and Pokeweed Mitogen-Induced in vitro IgM Production in Children and Adolescents with Insulin-Dependent Diabetes mellitus

1989

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Serum IgA, IgG and IgM levels, spontaneous and pokeweed mitogen (PWM)-induced in vitro IgM production (determined by ELISA) and blastogenic responses of peripheral mononuclear cells to PWM were evaluated in 4 insulin-dependent (IDDM) children, at the onset and after 4, 8, 12 months of disease, and in 32 children and adolescents with IDDM of 1–14 years duration (mean 4.8 ± 3.8 years). Fifteen age-matched healthy subjects served as controls. Serum immunoglobulin levels were normal in 31 (86%) patients. Spontaneous in vitro IgM production showed no significant difference between IDDM patients and controls. The PWM-stimulated lymphocytes from IDDM patients at onset or after 4 months of disease produced significantly lower concentrations of IgM compared to long-standing IDDM patients or to controls. No different blastogenic response to PWM was observed in IDDM patients compared to controls. No correlation was present between the immunological parameters evaluated and metabolic control. Our data suggest that a defect of antibody producing B lymphocytes or an alteration of T cell can occur during the early stages of diabetes.

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