Transient Hypogammaglobulinemia of Infancy

McGeady, Stephen J.

doi:10.1016/b978-0-12-405546-9.00018-2

Cited by 3 publications

(3 citation statements)

References 47 publications

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“…In early reports, THI was a rare condition, with several papers noting scant numbers of cases compared with other immune deficiencies. Later, however, probably reflecting greater awareness of the diagnosis, a larger series of cases began to be reported, and a greater relative frequency of THI” [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

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A Systematic Review of the Clinical Diagnosis of Transient Hypogammaglobulinemia of Infancy

Justiz-Vaillant,

Hoyte,

Davis

et al. 2023

Children

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Transient hypogammaglobulinemia of infancy (THI) is a primary immunodeficiency caused by a temporary decline in serum immunoglobulin G (IgG) levels greater than two standard deviations below the mean age-specific reference values in infants between 5 and 24 months of age. Preterm infants are particularly susceptible to THI, as IgG is only transferred across the placenta from mother to infant during the third trimester of pregnancy. This study aimed to conduct a systematic review of the diagnostic criteria for transient hypogammaglobulinemia of infancy. Systematic review: Three electronic databases (PubMed, MEDLINE, and Google Scholar) were manually searched from September 2021 to April 2022. Abstracts were screened to assess their fit to the inclusion criteria. Data were extracted from the selected studies using an adapted extraction tool (Cochrane). The studies were then assessed for bias using an assessment tool adapted from Cochrane. Of the 215 identified articles, 16 were eligible for examining the diagnostic criteria of THI. These studies were also assessed for bias in the six domains. A total of five studies (31%) had a low risk of bias, while four studies (25%) had a high risk of bias, and bias in the case of seven studies (44%) was unclear. We conclude that THI is only definitively diagnosed after abnormal IgG levels normalise. Hence, THI is not a benign condition, and monitoring for subsequent recurrent infections must be conducted. The diagnostic criteria should also include vaccine and isohaemagglutinin responses to differentiate THI from other immunological disorders in infants.

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Section: Discussionmentioning

confidence: 99%

“…Table 3 summarises the incidence of THI in selected countries. 10% of all cases of hypogammaglobulinemia/Taiwan [33] 18.5% of all cases of PID (the most prevalent/Japan [33] The estimated frequency of transient hypogammaglobulinemia varies among studies. In some studies, IgG deficiency was most common in childhood.…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of the Clinical Diagnosis of Transient Hypogammaglobulinemia of Infancy

Justiz-Vaillant,

Hoyte,

Davis

et al. 2023

Children

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“…1,2 THI is a diagnosis of exclusion. 6 Selective serum IgA deficiency is relatively common in children and adults. The estimated prevalence is between one in 200 and one in 1,000.…”

Section: Authorsmentioning

confidence: 99%

A Review of Primary Immune Deficiency Disorders

Darian

Freij

Seth

et al. 2020

EMJ Allergy Immunol

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Administrative Constitutionalism and the Unity of Public Law

Lewans

2018

SSRN Journal

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Public law scholarship in the common law tradition often aims at elucidating a connection between law and constitutional values like equality, due process, and the rule of law. However, in their quest to reveal the morality of public law, common lawyers often focus their attention on judicial interpretations of constitutional values to the exclusion of other sources of constitutional jurisprudence. The author argues that the traditional fascination with courts as the primary or exclusive arbiters of constitutional values should be tempered and supplemented by recognizing the valuable contributions of administrative officials who interpret and enforce constitutional norms when exercising statutorily delegated legal authority. By drawing attention to the contributions of the Canadian Human Rights Commission and Tribunal in advancing equality rights, the author argues that recent decisions from the Supreme Court of Canada which recommend judicial deference to reasonable, proportionate, and contextually sensitive administrative decisions concerning human rights, instead of resorting reflexively to correctness review, will serve to strengthen the moral unity of Canadian public law.

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Transient Hypogammaglobulinemia of Infancy

Cited by 3 publications

References 47 publications

A Systematic Review of the Clinical Diagnosis of Transient Hypogammaglobulinemia of Infancy

A Systematic Review of the Clinical Diagnosis of Transient Hypogammaglobulinemia of Infancy

A Review of Primary Immune Deficiency Disorders

Administrative Constitutionalism and the Unity of Public Law

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