Transient impairment of flow-mediated vasodilation in patients with metabolic syndrome at moderate altitude (1700 m)

Frick, Matthias; Rinner, Alexander; Mair, Johannes; Alber, Hannes; Mittermayr, Markus; Pachinger, Otmar; Humpeler, Egon; Schobersberger, Wolfgang; Weidinger, Franz

doi:10.1016/j.ijcard.2005.05.052

Cited by 18 publications

(21 citation statements)

References 33 publications

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“…Although our results showed that the vascular adaptations were induced by hypoxic training, FMD reportedly decreased significantly after 3 weeks of physical activities at mild altitude (1700 m above sea level) [72], or endothelium-dependent vasodilation did not change significantly with only intermittent hypoxic exposure (15% O 2 , Fig. 2 Changes in diameter of popliteal artery and %FMD before and after exercise training.…”

Section: Discussionmentioning

confidence: 52%

“…Furthermore, animal studies indicated that hypoxic exposure (2800 m above sea level) with exercise training depressed endothelium-dependent vasorelaxation [73,74]. At the moment, causes of the conflicting findings between this investigation and previous studies [24,72] are hard to explain. However, our protocol was composed of lowintensity exercise and intermittent exposure to a mild hypoxic environment.…”

Section: Discussionmentioning

confidence: 64%

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Vascular adaptations to hypobaric hypoxic training in postmenopausal women

et al. 2010

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The objective of this study was to examine the effects of exercise training in hypoxia on arterial stiffness and flow-mediated vasodilation (FMD) in postmenopausal women. Sixteen postmenopausal women (56±1 years) were assigned to a normoxic exercise group (Normoxic group, n=8) or a hypoxic exercise group (Hypoxic group, n=8). The Hypoxic group performed exercise under hypobaric hypoxic conditions corresponding to 2000 m above sea level, and was exposed to these conditions for 2 h per session. Aquatic exercise was performed at an intensity of around 50% peak oxygen uptake for 30min, 4days per week, for 8 weeks. Arterial stiffness was assessed by brachial-ankle pulse wave velocity (baPWV), and FMD was evaluated by peak diameter of the popliteal artery during reactive hyperemia. After the 8 weeks of training, the Normoxic group showed no significant changes. In contrast, baPWV (P < 0.05) was significantly reduced and peak diameter (P<0.05) and %FMD (P<0.01) were significantly increased in the Hypoxic group after training. These results suggest that exercise training under mild intermittent hypoxic conditions could more effectively reduce arterial stiffness in postmenopausal women, compared with exercise training performed at the same relative intensity under normoxic conditions. Our data also indicate that hypoxic exercise training may induce vascular functional adaptation, for example an increase in FMD response. These findings therefore could have important implications for the development of a new effective exercise prescription program.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 64%

Vascular adaptations to hypobaric hypoxic training in postmenopausal women

et al. 2010

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“…& No adverse effects in any volunteer during the 3-week vacation & No impairment of cardiac function due to moderate hypoxia as evaluated by echocardiographic analyses [9] but a transient reduction of flow-mediated dilation of brachial arteries at the end of vacation [10] & Reduction in systolic and diastolic blood pressure in both groups beginning within the first week of the vacation and lasting during the whole vacation (Table 1; The number of vacationers visiting moderate altitudes for recreational purposes remaining only a few days is still increasing. Among these Alpine guests, many suffer from high daily stress levels which they expect to be reduced by leisure and vacation activities.…”

Section: Amas I Main Studymentioning

confidence: 99%

Austrian Moderate Altitude Studies (AMAS): benefits of exposure to moderate altitudes (1,500–2,500 m)

et al. 2009

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“…In their study, Wyss et al [3] have shown that healthy subjects have preserved coronary flow reserve in response to high altitude exposure compared to those with coronary artery disease. Due to the absence of healthy control group in their study, Frick et al [1] have not assessed the basal microvascular endothelial status of their study population. It might be better and more informative to compare the effect of high altitude on flow mediated dilatation in patients with and without metabolic syndrome.…”

mentioning

confidence: 97%

“…In their recently published original article, Frick et al [1] have reported for the first time that patients with metabolic syndrome develop transient impairment of flow-mediated dilatation (endothelium-dependent vasodilatation) at moderate altitude (1700 m) using high resolution ultrasonographic examination of the brachial artery. The findings of this study are interesting and clinically significant when considering the high risk of atherosclerotic and atherothrombotic cardiovascular disease and its poor morbidity and mortality in patients with metabolic syndrome.…”

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confidence: 99%