2012
DOI: 10.1016/j.jacc.2011.10.894
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Transient Impairment of Vasomotion Function After Successful Chronic Total Occlusion Recanalization

Abstract: Recanalization of CTO is followed by a hibernation of vascular wall at distal coronary segments that fail to respond to endothelium-dependent and -independent stimuli. Distal vessel diameter increases over time in the absence of positive remodeling and in spite of persistent endothelial dysfunction. This severe impairment of vasomotor tone after CTO reopening suggests that intracoronary ultrasound assessment is of paramount importance for the selection of stent size.

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Cited by 86 publications
(47 citation statements)
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“…The recanalization of CTO is usually associated with better long-term outcomes. 1,2) However, the CTO recanalization success rate is variable and its main challenge is to advance the guidewire through the occlusion segment. Recently, the overall success rate has increased, thanks to the introduction of multiple intervention strategies, such as the parallel wire technique, 3) confluent balloon technique, 4) reverse controlled anterograde and retrograde sub-intimal tracking (CART) or reverse-CART technology, 5) as well as the development of new equipment.…”
Section: T Is Of Great Interest For Treating Chronic Total Occlusionmentioning
confidence: 99%
“…The recanalization of CTO is usually associated with better long-term outcomes. 1,2) However, the CTO recanalization success rate is variable and its main challenge is to advance the guidewire through the occlusion segment. Recently, the overall success rate has increased, thanks to the introduction of multiple intervention strategies, such as the parallel wire technique, 3) confluent balloon technique, 4) reverse controlled anterograde and retrograde sub-intimal tracking (CART) or reverse-CART technology, 5) as well as the development of new equipment.…”
Section: T Is Of Great Interest For Treating Chronic Total Occlusionmentioning
confidence: 99%
“…Even after successful revascularization of the target lesion, the vessel may not dilate immediately because of impaired endothelial function. 15 In our study, intracoronary nitrates were administered before CAG or IVUS imaging. Therefore, not only endothelium-dependent but also endothelium-independent vessel dilatation of the distal segments may be impaired.…”
Section: Study Limitationsmentioning
confidence: 99%
“…Therefore, not only endothelium-dependent but also endothelium-independent vessel dilatation of the distal segments may be impaired. 15 Vessel shrinkage may occur during coronary spasm or compression of the coronary artery by a myocardial bridge. Coronary spasm can be excluded by the administration of nitrates.…”
Section: Study Limitationsmentioning
confidence: 99%
“…However, automatic analysis of OCT sequence is likely to provide much more information, such as score maps and quantitative diagnosis indices. Automatic tools are becoming more efficient in cardiology particularly artery diseases, for example in chronic total occlusion recanalization [7,8]. Then, several studies developed automatic algorithm in order to detect the lumen border and the struts in OCT sequences [9][10][11][12][13][14][15] whereas Wang et al stayed focused only on the strut detection [16].…”
Section: Introductionmentioning
confidence: 99%