Transient Improvement of Hypertension-Induced Chronic Renal Failure with Mycophenolate Mofetil Treatment

Novel avenues to control blood pressure: targeting the renal lymphatic system

“…A positive effect of MMF in the reduction in blood pressure was also observed in spontaneous hypertensive rats in a salt-independent manner [ 8 ]. Importantly, MMF also reduced blood pressure in a small group of hypertensive patients [ 9 ], showing the importance of the immune system for the regulation of blood pressure in humans. It was later shown that T lymphocytes are specifically required to the development of hypertension in Angiotensin-II and DOCA-salt models of hypertension [ 10 ], shedding light on the relevance of specific cell populations as a regulator of systemic blood pressure.…”