Transient inactivation of the nucleus accumbens reduces both the expression and acquisition of morphine-induced conditioned place preference in rats

Esmaeili, Mohammad; Sahraei, Hedayat; Ali-Beig, Hengameh; Ardehari-Ghaleh, Mojgan; Mohammadian, Z; Zardooz, Homeira; Salimi, Seyed Hassan; Shams, Jamal; Noroozzadeh, Ali

doi:10.1016/j.pbb.2012.04.015

Cited by 12 publications

(16 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agreement with these data, increased NAc immediate early gene expression during opioid withdrawal and reinstatement supports the upregulation of NAc neural reactivity during withdrawal [42], [43]. Conversely, blocking NAc activity could reduce mCPP expression and prevent opioid relapse [27]. As is shown previously, membrane depolarization and increase of spiking are essential manifestations after central TRPV1 activation [20], [26], which is mediated by its modulatory on K + and Ca 2+ conductance or direct Ca 2+ and Na + influx via the channel itself.…”

Section: Discussionsupporting

confidence: 81%

“…As is shown previously, membrane depolarization and increase of spiking are essential manifestations after central TRPV1 activation [20], [26], which is mediated by its modulatory on K + and Ca 2+ conductance or direct Ca 2+ and Na + influx via the channel itself. Accordingly, blockade of NAc TRPV1, may contribute to limit neural activity in this region, which was confirmed to have relapse-preventing effect [27]. Further studies are necessary to elucidate the above and other mechanisms involved in the action of central, especially NAc, TRPV1 antagonism on drug addiction.…”

Section: Discussionmentioning

confidence: 85%

“…TRPV1 agonist could increase the spike frequency of neurons in ventral tegmental area [26]. These observations strongly suggested that NAc TRPV1 antagonism might perform anti-relapse effect by limiting neuronal activity and diminishing the efficacy of excitatory inputs from presynaptic terminals, which could reduce morphine conditioned place preference (mCPP) expression [27].…”

Section: Introductionmentioning

confidence: 92%

See 2 more Smart Citations

Blocking TRPV1 in Nucleus Accumbens Inhibits Persistent Morphine Conditioned Place Preference Expression in Rats

et al. 2014

View full text Add to dashboard Cite

The function of TRPV1 (transient receptor potential vanilloid subfamily, member 1) in the central nervous system is gradually elucidated. It has been recently proved to be expressed in nucleus accumbens (NAc), a region playing an essential role in mediating opioid craving and taking behaviors. Based on the general role of TRPV1 antagonist in blocking neural over-excitability by both pre- and post-synaptic mechanisms, TRPV1 antagonist capsazepine (CPZ) was tested for its ability to prohibit persistent opioid craving in rats. In the present study, we assessed the expression of TRPV1 in nucleus accumbens and investigated the effect of CPZ in bilateral nucleus accumbens on persistent morphine conditioned place preference (mCPP) in rats. We also evaluated the side-effect of CPZ on activity by comparing cross-beam times between groups. We found that morphine conditioned place preference increased the TRPV1 expression and CPZ attenuated morphine conditioned place preference in a dose-dependent and target–specific manner after both short- and long-term spontaneous withdrawal, reflected by the reduction of the increased time in morphine-paired side. CPZ (10 nM) could induce prolonged and stable inhibition of morphine conditioned place preference expression. More importantly, CPZ did not cause dysfunction of activity in the subjects tested, which indicates the inhibitory effect was not obtained at the sacrifice of regular movement. Collectively, these results indicated that injection of TRPV1 antagonist in nucleus accumbens is capable of attenuating persistent morphine conditioned place preference without affecting normal activity. Thus, TRPV1 antagonist is one of the promising therapeutic drugs for the treatment of opioid addiction.

show abstract

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 92%

See 1 more Smart Citation

Blocking TRPV1 in Nucleus Accumbens Inhibits Persistent Morphine Conditioned Place Preference Expression in Rats

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Our earlier study indicated that an asymmetry between the right and left sides of NAcC may exist in morphine reward [14]. In addition, the asymmetry is also manifested with respect to locomotion activity [14][15][16]. However, the possible important role of this asymmetry in nicotine reward was not clear.…”

Section: Introductionmentioning

confidence: 95%

“…There are reasons to believe that the Sh part of the NAc after nicotine introduction initiates nicotine rewarding properties, while the C part may play a role in the nicotine conditioning (Pavlovian type) [3]. Our earlier study indicated that an asymmetry between the right and left sides of NAcC may exist in morphine reward [14]. In addition, the asymmetry is also manifested with respect to locomotion activity [14][15][16].…”

Section: Introductionmentioning

confidence: 98%

Inactivation of the Nucl. Accumbens Core Exerts No Effect on Nicotine-Induced Conditioned Place Preference

et al. 2015

View full text Add to dashboard Cite

Effects of transient inhibition of the core part of the nucl. accumbens (NAcC) by lidocaine on nicotine-induced conditioned place preference in male Wistar rats were examined. Lidocaine (2%) was injected into the NAcC of nicotine-conditioned animals before each nicotine i.p. injection. On the test day, behavior of the animals in a two-compartment apparatus was recorded during 10 min. Results revealed that i.p. injections of nicotine (1.0 or 1.5 mg/kg) induced place preference. Transient lidocaine-induced inhibition of one or both sides of the NAcC did not change place preference but changed the numbers of compartment crossings, rearings, and sniffings. Inhibition of the left part and both parts of the structure reduced sniffing and increased place preference; inhibition of the right part of the nucleus increased the intensity of this phenomena. Keywords: nicotine, conditioned place preference, lidocaine, core part of the nucl. accumbens, shell part of the nucl. accumbens, rat.

show abstract

The role of nucleus accumbens shell on acquisition and retrieval stages of morphine state dependent learning

Noorbakhshnia

Zarrinimehr

2019

Asian Journal of Psychiatry

View full text Add to dashboard Cite

Transient inactivation of the nucleus accumbens reduces both the expression and acquisition of morphine-induced conditioned place preference in rats

Cited by 12 publications

References 62 publications

Blocking TRPV1 in Nucleus Accumbens Inhibits Persistent Morphine Conditioned Place Preference Expression in Rats

Blocking TRPV1 in Nucleus Accumbens Inhibits Persistent Morphine Conditioned Place Preference Expression in Rats

Inactivation of the Nucl. Accumbens Core Exerts No Effect on Nicotine-Induced Conditioned Place Preference

The role of nucleus accumbens shell on acquisition and retrieval stages of morphine state dependent learning

Contact Info

Product

Resources

About