Transient Intestinal Carriage after Ingestion of Antibiotic-Resistant<i>Enterococcus faecium</i>from Chicken and Pork

Sørensen, Thomas Lund; Blom, Marianne; Monnet, Dominique; Frimodt‐Møller, Niels; Poulsen, Rikke Lykke; Espersen, Frank

doi:10.1056/nejmoa010692

Cited by 157 publications

(111 citation statements)

References 20 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…The authors therefore suggested either a mutual spread of resistant enterococci between humans and pigs, or the existence of a common reservoir of resistant enterococci. The hypothesis that animals can be a source of resistant enterococci for humans could be supported by the findings of Sorensen et al [65]. In the latter study, the survival of animal derived enterococcal strains in the human intestine was investigated in 18 volunteers.…”

Section: Transmission Of Tetracycline and Mls Resistancementioning

confidence: 86%

Resistance to the tetracyclines and macrolide-lincosamide-streptogramin group of antibiotics and its genetic linkage – a review

Marosevic¹,

Kaevska²,

Jaglič³

2017

Ann Agric Environ Med.

View full text Add to dashboard Cite

Marosevic D, Kaevska M, Jaglic Z. Resistance to the tetracyclines and macrolide-lincosamide-streptogramin group of antibiotics and its genetic linkage -a review. Ann Agric Environ Med. 2017; 24(2): 338-344. https://doi.org/10.26444/aaem/74718 AbstractAn excessive use of antimicrobial agents poses a risk for the selection of resistant bacteria. Of particular interest are antibiotics that have large consumption rates in both veterinary and human medicine, such as the tetracyclines and macrolidelincosamide-streptogramin (MLS) group of antibiotics. A high load of these agents increases the risk of transmission of resistant bacteria and/or resistance determinants to humans, leading to a subsequent therapeutic failure. An increasing incidence of bacteria resistant to both tetracyclines and MLS antibiotics has been recently observed. This review summarizes the current knowledge on different tetracycline and MLS resistance genes that can be linked together on transposable elements.

show abstract

Section: Transmission Of Tetracycline and Mls Resistancementioning

confidence: 86%

Resistance to the tetracyclines and macrolide-lincosamide-streptogramin group of antibiotics and its genetic linkage – a review

Marosevic¹,

Kaevska²,

Jaglič³

2017

Ann Agric Environ Med.

View full text Add to dashboard Cite

show abstract

“…Frequent empirical-based antibiotic therapy of humans, the addition of antibiotics as growth promotants in livestock feed, and antibiotic misuse have been implicated in the selective proliferation of resistant strains (Pantosti et al, 1999;Del Grosso et al, 2000;Mateu and Martin, 2001;O'Brien, 2002;Hershberger et al, 2005). The transmission of antimicrobial-resistant strains of pathogenic bacteria to humans is of increasing significance (Sørensen et al, 2001;Kuehn, 2007). In addition to direct colonization, public health costs include reduced efficacy of empirical antibiotic use, reduced choices for treatment, and possible coselection of virulence traits among pathogens (Mølbak, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…in nosocomial infections, many have suggested that the hospital setting serves as the reservoir for antimicrobial-resistant strains (Ruiz-Garbajosa et al, 2006). Additional studies suggest environmental sources of the bacteria, including animals, can serve as important reservoirs for antimicrobialresistant Enterococcus strains (Sørensen et al, 2001;Mallon et al, 2002). Studies have demonstrated a link between human sources of resistant strains of Enterococcus isolates and the environment, and have suggested that animals and their products are contaminated secondary to interaction with humans and the environment (Aarestrup et al, 1995;Iversen et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Antibiotic-Resistance Characteristics of Enterococcus Spp. Isolated From Free-Living and Captive Raptors in Central Illinois

Marrow

Whittington

Mitchell

et al. 2009

Journal of Wildlife Diseases

View full text Add to dashboard Cite

ABSTRACT:Due to their predatory nature, raptor species may serve as important indicators of environmental contamination with antimicrobial-resistant bacteria. Raptors prey on small rodents and birds that have diverse habitat ranges, including urban and rural environments, and their intestinal microflora can reflect that of the animals on which they feed. Enterococcus spp. were selected as target organisms because they have been isolated from the avian gastrointestinal tract, can be conferred by prey items, and because they are capable of multiple resistance patterns. They are also a concerning source of human antimicrobial resistance. In this study fecal cultures were obtained from 15 May 2004 to 31 August 2004, from 21 free-living raptors and four captive raptors. Enterococcus was isolated from 21 (84%) of the 25 birds, and 54 isolates were chosen for further study based upon unique colony morphology. The most common isolate recovered was Enterococcus faecalis (95%, 95% confidence interval [CI]: 89-100). One bird in the study was determined to have Enterococcus gallinarum. Two distinct ribotypes of E. faecalis were identified, one with unique bands at 11 and 13 kb and the other with unique bands at 14 and 20 kb. Both ribotypes were found in free-living and captive birds. The Enterococcus isolates in this study demonstrated a variety of antimicrobial-resistance characteristics, including almost complete resistance to amikacin, first-generation cephalosporins, spectinomycin, and sulphadimethoxime. Isolates demonstrated variable resistance to chloramphenicol, gentamicin, enrofloxacin, erythromycin, and ticarcillin. No phenotypically vancomycin-resistant E. faecalis isolates were recovered from any of the raptors; three isolates had intermediate level susceptibility. A significantly higher number of isolates collected from captive birds demonstrated resistance to chloramphenicol than those obtained from free-living birds. This trend was not duplicated with any of the remaining 18 antimicrobial drugs tested. The results of this study suggest that raptors in central Illinois are coming into contact with antimicrobials, prey exposed to antimicrobials, or bacteria that are capable of transferring resistance genes. Further study is needed to determine the source of antimicrobial-resistant Enterococcus in free-living raptors but the limited data reflecting few differences between birds with and without antimicrobial exposure suggests that treatment and release of treated wild raptors is not contributing significantly to antimicrobial resistance in the environment.

show abstract

“…Of particular interest has been the potential for foods as a vehicle for transmission of these strains to humans or, alternatively, as a reservoir for horizontal transfer between strains. This might be considered credible since once ingested, enterococci can survive gastric passage, multiply, and colonize the gastrointestinal tract for a significant amount of time (24). Indeed, there is strong epidemiological evidence to link the use of antibiotics in human medicine and animal agriculture with the presence of resistant strains in animal products.…”

mentioning

confidence: 99%

Antimicrobial Resistance of Enterococcus Species Isolated from Produce

Johnston

Jaykus

2004

Appl Environ Microbiol

View full text Add to dashboard Cite

The purpose of this study was to characterize the antibiotic resistance profiles of Enterococcus species isolated from fresh produce harvested in the southwestern United States. Among the 185 Enterococcus isolates obtained, 97 (52%) were Enterococcus faecium, 38 (21%) were Enterococcus faecalis, and 50 (27%) were other Enterococcus species. Of human clinical importance, E. faecium strains had a much higher prevalence of resistance to ciprofloxacin, tetracycline, and nitrofurantoin than E. faecalis. E. faecalis strains had a low prevalence of resistance to antibiotics used to treat E. faecalis infections of both clinical and of agricultural relevance, excluding its intrinsic resistance patterns. Thirty-four percent of the isolates had multiple-drugresistance patterns, excluding intrinsic resistance. Data on the prevalence and types of antibiotic resistance in Enterococcus species isolated from fresh produce may be used to describe baseline antibiotic susceptibility profiles associated with Enterococcus spp. isolated from the environment. The data collected may also help elucidate the role of foods in the transmission of antibiotic-resistant strains to human populations.

show abstract

Transient Intestinal Carriage after Ingestion of Antibiotic-ResistantEnterococcus faeciumfrom Chicken and Pork

Abstract: The ingestion of resistant E. faecium of animal origin leads to detectable concentrations of the resistant strain in stools for up to 14 days after ingestion. The organisms survive gastric passage and multiply.

Cited by 157 publications

References 20 publications

Resistance to the tetracyclines and macrolide-lincosamide-streptogramin group of antibiotics and its genetic linkage – a review

Resistance to the tetracyclines and macrolide-lincosamide-streptogramin group of antibiotics and its genetic linkage – a review

Prevalence and Antibiotic-Resistance Characteristics of Enterococcus Spp. Isolated From Free-Living and Captive Raptors in Central Illinois

Antimicrobial Resistance of Enterococcus Species Isolated from Produce

Contact Info

Product

Resources

About