Transient ischemic dilation ratio (TID) correlates with HbA1C in patients with diabetes type 2 with proven myocardial ischemia according to exercise myocardial SPECT

Adamíková, Alena; Bakala, Jiří; Bernatek, J; Rybka, J; Svačina, Š

doi:10.1007/bf02984659

Cited by 7 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many MPI indices are associated with myocardial perfusion abnormalities and coronary artery disease. SRLVV ratio is higher in persons with diabetes [27][28][29][30], particularly those who later develop cardiac events. Subendocardial ischemia or stress-induced stunning [31] may cause TID, which is an independent predictor of future cardiac events [8,31].…”

Section: Discussionmentioning

confidence: 95%

Folate therapy improves the stress-to-rest mean LV volume ratio in myocardial perfusion imaging in patients with diabetes

et al. 2015

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 95%

Folate therapy improves the stress-to-rest mean LV volume ratio in myocardial perfusion imaging in patients with diabetes

et al. 2015

View full text Add to dashboard Cite

show abstract

“…13 These findings raise important questions about the pathophysiology and the diagnostic and prognostic value of TID in the presence of diabetes mellitus. Recently, Petretta et al 14 found that TID provides incremental diagnostic information over standard myocardial perfusion analysis for the identification of severe and extensive CAD in patients with diabetes mellitus.…”

Section: Clinical Perspective On P 915mentioning

confidence: 99%

Transient Ischemic Dilation in Patients With Diabetes Mellitus

Petretta

Acampa

Daniele

et al. 2013

Circ: Cardiovascular Imaging

View full text Add to dashboard Cite

Background-We prospectively evaluated the incremental prognostic value of transient ischemic dilation (TID) in patients with type 2 diabetes mellitus during long-term follow-up and estimated cardiac death and nonfatal myocardial infarction (MI) using traditional approaches of prognostication to more recent methods. Methods and Results-A total of 672 consecutive diabetic patients with available rest and stress gated myocardial perfusion single-photon emission computed tomographic data were enrolled. Stepwise Cox regression analysis was used to estimate cardiac death or nonfatal MI. Risk reclassification was calculated, and an exploratory analysis was performed to evaluate the effect of coronary revascularization on event-free survival. Adding TID to a multivariable model, including age, history of MI, stress type, poststress left ventricular ejection fraction, and stress-induced myocardial ischemia, improved discrimination of cardiac death or nonfatal MI (C statistic, 0.74-0.82; P=0.01; adjusted hazard ratio, 3.6; P<0.0001) and led to a net reclassification improvement of 0.39 (95% confidence interval, 0.14-0.64). Revascularization had a significant effect on event-free survival (adjusted hazard ratio, 0.25; P<0.001), with significant interactions between revascularization and poststress left ventricular ejection fraction, revascularization and stress-induced myocardial ischemia, and revascularization and TID (all P<0.01) Conclusions-TID provides independent and incremental prognostic information for the prediction of cardiac death or nonfatal MI in patients with diabetes mellitus. The addition of TID to a prediction model based on cardiovascular risk factors, left ventricular ejection fraction, and ischemia significantly improves risk discrimination and reclassification for incident cardiac events. The effect of revascularization seems to be influenced by left ventricular systolic function, stressinduced myocardial ischemia, and TID. (Circ Cardiovasc Imaging. 2013;6:908-915.)

show abstract

“…Thus, the findings suggested exercise-induced systolic (as well as possibly diastolic) left ventricular dysfunction, and along with autonomic neuropathy, the presence of diabetic cardiomyopathy. Transient ischemic left ventricular dilatation (TID) shown by a stress myocardial perfusion SPECT scan is a marker of the presence of severe coronary artery disease [6,7]. The patient had a normal TID value as well as negative exercise testing result.…”

Section: Case Reportmentioning

confidence: 99%

Diabetic Cardiomyopathy - Heart Disease in Diabetes

Adamíková¹,

Bakala²,

Paterova³

et al. 2013

CMR

Self Cite

View full text Add to dashboard Cite

Diabetic cardiomyopathy is defined as a finding of systolic and diastolic left ventricular dysfunction, myocardial dilation and left ventricular hypertrophy without the presence of macroangiopathy and hypertension. Causes include metabolic changes, myocardial fibrosis, microangiopathy as well as cardiovascular autonomic neuropathy leading to sympathetic denervation and alteration of myocardial perfusion. It comprises abnormalities in the control of heart rate as well as central and peripheral vascular dynamics. The diagnosis of diabetic cardiomyopathy affects significantly the prognosis in patients with diabetes. Echocardiography and nuclear medicine methods are used for diagnosis.

show abstract

Transient ischemic dilation ratio (TID) correlates with HbA1C in patients with diabetes type 2 with proven myocardial ischemia according to exercise myocardial SPECT

Abstract: Diabetes and its long- term unsatisfactory compensation can be one of the factors which affect left ventricular transient ischemic dilation.

Cited by 7 publications

References 14 publications

Folate therapy improves the stress-to-rest mean LV volume ratio in myocardial perfusion imaging in patients with diabetes

Folate therapy improves the stress-to-rest mean LV volume ratio in myocardial perfusion imaging in patients with diabetes

Transient Ischemic Dilation in Patients With Diabetes Mellitus

Diabetic Cardiomyopathy - Heart Disease in Diabetes

Contact Info

Product

Resources

About