Transient left homonymous hemianopsia and encephalopathy following treatment of testicular carcinoma with cisplatinum, vinblastine, and bleomycin.

Cohen, Ruben; Cuneo, R A; Cruciger, M P; Jackman, A. E.

doi:10.1200/jco.1983.1.6.392

Cited by 49 publications

(17 citation statements)

References 2 publications

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“…In our case report, we postulate a direct toxic effect of carboplatin, as it was described in the 1970s for cisplatin [5,6,7,8,9,10,11,12,13]. In the case of cisplatin cortical blindness, macula degeneration, retrobulbar neuritis and papilledema were described.…”

Section: Discussionsupporting

confidence: 53%

Carboplatin-Induced Bilateral Papilledema: A Case Report

Fischer¹,

Stuermer

Rodic

et al. 2009

Case Rep Oncol

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We report on a patient with carboplatin-induced bilateral papilledema, as it was described in the 1970s for cisplatin. Loss of visual accuracy up to full blindness, often loss of color vision and scotomas can be seen as a result of cortical blindness, macula degeneration, retrobulbar neuritis and papilledema. These symptoms are mostly unilateral and initially mild, so that more chemotherapy is given before the diagnosis is made. The symptoms are usually reversible within weeks to months after cessation of the platinum treatment. The therapeutic strategy is stopping the platinum treatment. In addition the empiric use of corticosteroids is suggested.

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Section: Discussionsupporting

confidence: 53%

Carboplatin-Induced Bilateral Papilledema: A Case Report

Fischer¹,

Stuermer

Rodic

et al. 2009

Case Rep Oncol

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“…This hypothesis was based on a high level of cisplatin found in the patient s cerebrospinal fluid. In 1983 another case of cortical blindness and encephalopathy following chemotherapy for testicular carcinoma was de scribed [32]. The authors of this report interpreted their find ings in a similar manner as Berman and Mann [31].…”

Section: Cerebrovascular Accidentsupporting

confidence: 59%

Acute and Late Vascular Complications Following Chemotherapy for Germ Cell Tumors

Gerl¹,

Clemm²,

Wilmanns³

1993

Oncol Res Treat

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Side effects of cisplatin-based chemotherapy for germ cell tumors include myelosup-pression, nephro-, neuro- and ototoxicity. These side effects as well as the pulmonary toxicity of bleomycin are dose-dependent. On the contrary, chemotherapy-associated vascular complications are unpredictable. Whereas Raynaud’s phenomenon is observed in a considerable proportion of patients, myocardial infarction, stroke, and pulmonary embolism appear to occur infrequently. The fact that some patients have been in complete remission at the time of myocardial infarction or cerebrovascular accident argues against a tumor-induced complication and is an argument in favor of a possible causative role of chemotherapy. An alteration of the clotting system and vascular smooth muscle tone as well as an endothelial cell damage are discussed to be pathogenetic mechanisms. Pulmonary embolism, on the contrary, seems to be more frequently associated with inferior vena caval obstruction by tumor masses. Presently there is a debate whether, apart from rare acute vascular events, chemotherapy for testicular cancer leads to a long-term alteration of lipid profile and thereby eventually increases cardiovascular risk.

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“…In this case and others, it was most prominent where the lesion faced the deep white matter [3][4][5][6][8][9][10]. The lesion margin in proximity to the cortex did not enhance (see Fig I, images 2 and l 0).…”

mentioning

confidence: 69%

lnterleukin‐2 and Cisplatinum Therapy Toxicity Mimicking Basilar Artery Disease

Estol¹,

Atkins²,

Mier³

et al. 1993

Journal of Neuroimaging

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A 51-year -old woman receiving cis-platinum and interleukin-2 for metastatic melanoma developed a clinical picture suggesting basilar artery occlusion. Magnetic resonance imaging and computed tomography showed bilateral occipital lucencies.Received May 13, 1991, and in revised form Sep 16, 1991, and Oct 21, 1992. Accepted for publication Oct 22, 1992. Address correspondence to Dr Estol. Copyright © 1993 by the American Society of Neuroimaging 145She recovered slowly and the imaging abnormalities resolved.Estol CJ, Atkins M. Mier JM. Caplan LR.lnterleukin-2 and cis-platinum therapy toxicity mimicking basilar artery disease.

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Transient left homonymous hemianopsia and encephalopathy following treatment of testicular carcinoma with cisplatinum, vinblastine, and bleomycin.

Cited by 49 publications

References 2 publications

Carboplatin-Induced Bilateral Papilledema: A Case Report

Carboplatin-Induced Bilateral Papilledema: A Case Report

Acute and Late Vascular Complications Following Chemotherapy for Germ Cell Tumors

lnterleukin‐2 and Cisplatinum Therapy Toxicity Mimicking Basilar Artery Disease

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