“…In fact, in some publications of series of patients, even recognizing the presence of a mitochondrial disease, authors viewed the signal changes as a direct consequence of seizures [1,5,8]. In 1 report of 6 infants with infantile spasms and subcortical gray matter restriction of diffusion, authors consider the SIE as the main hypothesis to explain the cytotoxic edema [9]. Later, it was realized that vigabatrin could lead to this MRI pattern [10].…”