Transient Neonatal Diabetes Mellitus and Seizure with an Unknown Etiology

Abstract

Neonatal diabetes mellitus (NDM) is a monogenic form of diabetes, usually occurring in the first 6 months of life. Here, we present a newborn, which was admitted with epileptic seizure on the postnatal second day of life. Sepsis and meningitis were ruled out. Cranial imaging and electroencephalography revealed normal. She developed transient NDM on the follow-up and was diagnosed to carry an ABCC8 mutation. Although the neurological features are more common in patients with KCJN11 mutations, patients with ABCC8 mutations could also represent with subtle neurodevelopmental changes or even with epileptic seizures. The genetic testing and appropriate therapy is important in this patient group for predicting clinical course and possible additional features.

Neonatal Diabetes mellitus: A review

“…This type of diabetes emerges in first few weeks of life but it is transient. The fundamental mechanism of TNDM is dysregulation of pancreatic hormones depending upon the intensity of weakness in β cells (Gunes et al, 2021). Other symptom of TNDM is the gradual growth and development of neonates who is prone to hyperglycaemia and dehydration.…”