Transient Part-Solid Nodules Detected at Screening Thin-Section CT for Lung Cancer: Comparison with Persistent Part-Solid Nodules<sup />

Lee, Sang Min; Park, Chang Min; Goo, Jin Mo; Lee, Young Moo; Lee, Hyun Ju; Kim, Kwang Gi; Kang, Mi‐Jin; Lee, In Sun

doi:10.1148/radiol.09090547

Cited by 122 publications

(96 citation statements)

References 27 publications

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“…The high rate of transience represents the prevalence of eosinophilic pulmonary infiltrates in Korea, as about 33% of transient nodules were eosinophilic pulmonary infiltrates in our series. This trend is not restricted to a region, as other reports 8,10 from hospitals in a metropolitan capital city also reported the high prevalence of transient nodules in association with eosinophilia. We believe it is related to a dietary habit of Korean people.…”

Section: Discussionsupporting

confidence: 55%

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Proportion and characteristics of transient nodules in a retrospective analysis of pulmonary nodules

Lee

et al. 2012

Thoracic Cancer

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Background: Pulmonary nodules manifest as pure or mixed ground glass opacities (GGOs), or solid nodules. Methods: We retrospectively surveyed 317 cases with pulmonary nodules to observe the proportion and predictive factors of transient lesions in patients with pulmonary nodules. Results: At the initial computed tomography scan, 63.7% showed solid nodules, while 20.2% had mixed GGOs and 16.1% of cases manifested as pure GGOs. Nodules from 114 cases (36%) disappeared or decreased in size during follow up, while in 203 cases (64%), they did not change or became enlarged. During follow up, more than half of the GGOs resolved (66.7% in pure GGOs, 54.7% in mixed GGOs), while only 22.3% of solid nodules resolved. Between transient and persistent pulmonary nodules, significant differences were observed in age, gender, smoking history, presence of eosinophilia, size, and radiologic attenuation of nodules (solid or GGO). In multivariate analysis, age (Յ55 years), size of nodules (>15 mm), eosinophilia, and GGO were significant independent predictors of transient nodules. The main causes of transient nodules were pneumonia or eosinophilic pulmonary infiltrates. Conclusion: Thirty-six percent of pulmonary nodules resolved spontaneously or with medical treatment. Transient nodules showed different clinical and radiological characteristics from persistent nodules.

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Section: Discussionsupporting

confidence: 55%

“…Recently, Lee et al 10 reported a 69.8% of transience rate from 126 partly solid GGO nodules. They also observed that young patient age, blood eosinophilia, lesion multiplicity, large solid portion and ill-defined border were significant independent predictors of transience.…”

Section: Transient Pulmonary Nodulesmentioning

confidence: 98%

Proportion and characteristics of transient nodules in a retrospective analysis of pulmonary nodules

Lee

et al. 2012

Thoracic Cancer

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“…Transient SSNs are associated with infectious or inflammatory conditions, and blood eosinophilia is one of the wellknown causes of transient inflammation in the lung (1, 37). Lee et al (37) reported that transient SSNs are related to features such as a young patient age, detection at follow up, blood eosinophilia, lesion multiplicity, a large solid portion, and an ill-defined lesion border.…”

Section: Natural Clinical Course Of Subsolid Nodulesmentioning

confidence: 99%

Pulmonary subsolid nodules: what radiologists need to know about the imaging features and management strategy

Kim¹,

Park²,

Koh³

et al. 2013

Diagn Interv Radiol

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“…A single PSN is considered malignant until proven otherwise if it remains stable or grows on a 3-month follow-up scan An initial 3-month follow-up CT is recommended with PSNs to ensure persistence [16] . Malignant lesions may occasionally show a temporary decrease in size, due to contraction of a fibrotic or atelectatic component, and therefore a slight decrease in size should not constitute evidence of benignancy [17] .…”

Section: Recommendationmentioning

confidence: 99%

Incidental, subsolid pulmonary nodules at CT: etiology and management

Seidelman¹,

Quint²

2013

Cancer Imaging

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Pulmonary nodules, both solid and subsolid, are common incidental findings on computed tomography (CT) studies. Subsolid nodules (SSNs) may be further classified as either pure ground-glass nodules or part-solid nodules. The differential diagnosis for an SSN is broad, including infection, organizing pneumonia, inflammation, hemorrhage, focal fibrosis, and neoplasm. Adenocarcinomas of the lung are currently the most common type of lung cancer, representing 3035% of all primary lung tumors, and the subtype of bronchioloalveolar cell carcinoma (BAC) commonly presents as an SSN. In 2011, a new classification system for lung adenocarcinomas was proposed by the International Association for the Study of Lung Cancer, the American Thoracic Society, and the European Respiratory Society. An important feature of the new system is the relinquishment of the term BAC in favor of more specific histologic subtypes. It has been reported that these subtypes are associated with characteristic CT findings. This article reviews the new classification system of lung adenocarcinomas, discusses and illustrates the associated CT findings, and outlines the current recommendations for further diagnosis, treatment, and follow-up of SSNs based on computed tomography findings.

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Transient Part-Solid Nodules Detected at Screening Thin-Section CT for Lung Cancer: Comparison with Persistent Part-Solid Nodules

Cited by 122 publications

References 27 publications

Proportion and characteristics of transient nodules in a retrospective analysis of pulmonary nodules

Proportion and characteristics of transient nodules in a retrospective analysis of pulmonary nodules

Pulmonary subsolid nodules: what radiologists need to know about the imaging features and management strategy

Incidental, subsolid pulmonary nodules at CT: etiology and management

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