Purpose: To evaluate different vein grafts for luminal coating of endovascular stents in normal canine arteries. Methods: Twenty-four tantalum Strecker stents were coated with either autologous (n Å 10), denatured heterologous (n Å 11), or denatured homologous vein grafts (n Å 3). The carotid artery (n Å 11) and the iliac artery (n Å 13) were stented using a transfemoral approach. Angiograms were performed at days 0, 7, and 21, and months 3, 6, and 9. All grafts underwent histological examination. Results: Eight of 10 autologous vein grafts showed patency during the whole observation period of 9 months, without histological signs of inflammation. Denatured heterologous vein grafts revealed acute (n Å 3), subacute (n Å 5), or delayed (n Å 3) vessel occlusion. Hyaloid transformation of the vein graft and lymphoplasmacellular formations were seen. Denatured homologous vein grafts showed acute vessel occlusion. Although significant inflammatory tissue response was seen, no host-versus-graft reaction was present. Conclusion: Autologous vein graft-coated stents showed good biocompatibility in canine arteries. Preparation was cumbersome and required surgical venaesectio. Denatured vein grafts, however, were limited by inflammatory reactions.