Transient Psychosis After Low-Dose Pregabalin Discontinuation

Uçar, Hüseyin; Gündoğmuş, İbrahim; Bolu, Abdullah; Çeli̇k, Cemi̇l

doi:10.1097/mjt.0000000000001159

Cited by 5 publications

(6 citation statements)

References 7 publications

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“…It is also important to consider the duration of pregabalin use. Case 1 showed pregabalin withdrawal after only 2 months of pregabalin use, and previous reports have also shown pregabalin withdrawal in cases after a few weeks or 45 days of short‐term pregabalin use 8,11 . Case 1 was particularly worth reporting because it suggested that even a short period of a regular dose of pregabalin can cause physical dependence.…”

Section: Discussionmentioning

confidence: 74%

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Pregabalin withdrawal in patients without psychiatric disorders taking a regular dose of pregabalin: A case series and literature review

Ishikawa

Takeshima

Ishikawa

et al. 2021

Neuropsychopharm Rep

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Pregabalin is a drug that can cause psychiatric symptoms via pregabalin withdrawal. Prior reports on pregabalin withdrawal have mainly focused on cases with pregabalin dependence or abuse, and little attention has been paid to patients who are prescribed regular doses of pregabalin. Herein, we report three cases of pregabalin withdrawal in patients without psychiatric disorders, taking regular doses of pregabalin, who developed psychiatric symptoms such as insomnia and anxiety after abrupt discontinuation of pregabalin. In addition, we conducted a systematic review of six case reports (previous studies) of pregabalin withdrawal under regular doses of pregabalin. Among the six cases, three patients had no comorbid mental or substance use disorders, the dose of pregabalin ranged from 150 to 600 mg/d, and the duration of pregabalin use ranged from a few weeks to many years. Of these six cases of pregabalin withdrawal, five had psychopathological symptoms, three had vegetative symptoms, and three had neurologic and physical complications. We concluded that since pregabalin withdrawal can occur even with regular doses and short‐term use, clinicians must carefully reduce pregabalin doses when reducing or discontinuing treatment, paying close attention to withdrawal symptoms. Our case series sheds light on the scant evidence from previous research on physical dependence in patients who are taking regular doses of pregabalin. Furthermore, our cases were also valuable in demonstrating that pregabalin withdrawal can occur even after a relatively short period of 2 months.

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Section: Discussionmentioning

confidence: 74%

“…We identified 463 articles through the systematic literature search. Of these, six case reports (six cases) were identified in which withdrawal symptoms occurred in patients administered pregabalin at the usual dose of 600 mg/d or lower 8‐13 . Table 1 shows the demographic data and clinical symptoms of the six cases.…”

Section: Literature Reviewmentioning

confidence: 99%

Pregabalin withdrawal in patients without psychiatric disorders taking a regular dose of pregabalin: A case series and literature review

Ishikawa

Takeshima

Ishikawa

et al. 2021

Neuropsychopharm Rep

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“…One case study presents a 30-year-old female university graduate student with no history of substance abuse treated with 150 mg pregabalin/day because of diffuse body pain 8 . After abrupt discontinuation, she was admitted to the emergency department with a pregabalin withdrawal-associated psychotic episode.…”

Section: Resultsmentioning

confidence: 99%

“…Pregabalin causes a change in dopamine in the central nervous system, which causes a rewarding effect like in many other drugs of abuse 15 . This could also explain why pregabalin and gabapentin are often co-ingested with other drugs, as a synergistic effect occurs and the ‘high’ is potentiated as described in many studies 6–10,12,13 …”

Section: Discussionmentioning

confidence: 98%

“…15 This could also explain why pregabalin and gabapentin are often coingested with other drugs, as a synergistic effect occurs and the 'high' is potentiated as described in many studies. [6][7][8][9][10]12,13 The study by Isoardi et al 10 showed that only 6.7% of comas occurred with only pregabalin (median dose of 2400 mg) without co-ingesting other sedating drugs. In the study by Dufayet et al 11 five of eight patients (62.5%) who suffered from coma and generalized seizures reported ingesting pregabalin alone.…”

Section: Discussionmentioning

confidence: 99%

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A review of the addictive potential of pregabalin and gabapentin

Dalsgaard,

Dalhoff,

Heerfordt

2024

Adverse Drug Reaction Bulletin

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Summary Following increasing inquiries to the Danish Poison Information Centre regarding pregabalin and gabapentin, this review investigates existing literature about the addictive potential of these two drugs, with a focus on publications after 2020. A systematic search of PubMed was conducted to identify studies concerning the recreational use, misuse and withdrawal symptoms associated with pregabalin and gabapentin. Five case studies, three observational studies, and two interviews were included. This review highlights demographical variations in the misuse of the drugs. Notably, a high prevalence of recreational use of pregabalin was observed among adolescents often co-ingested with sedatives, such as opioids and alcohol. Withdrawal symptoms often followed abrupt discontinuation even at recommended doses, underscoring the drugs’ potential for physical dependence. This review adds information to the already existing literature and provides new insights into the misuse and abuse of pregabalin and gabapentin. This review supports the need for further monitoring and better patient education to mitigate the rising misuse.

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Pregabalin withdrawal

2022

Reactions Weekly

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Transient Psychosis After Low-Dose Pregabalin Discontinuation

Cited by 5 publications

References 7 publications

Pregabalin withdrawal in patients without psychiatric disorders taking a regular dose of pregabalin: A case series and literature review

Pregabalin withdrawal in patients without psychiatric disorders taking a regular dose of pregabalin: A case series and literature review

A review of the addictive potential of pregabalin and gabapentin

Pregabalin withdrawal

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