Transient Receptor Potential Melastatin 7 as an Independent Prognostic Factor in Human Esophageal Squamous Cell Carcinoma

Nakashima, Shingo; Shiozaki, Atsushi; Ichikawa, Daisuke; Hikami, Shoichiro; Kosuga, Toshiyuki; Konishi, Hirotaka; Komatsu, Shuhei; Fujiwara, Hitoshi; Okamoto, Kazuma; Kishimoto, Mitsuo; Konishi, Eiichi; Otsuji, Eigo

doi:10.21873/anticanres.11429

Cited by 20 publications

(7 citation statements)

References 27 publications

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“…Esophageal squamous cell carcinoma (ESCC) is a frequently occurring maligantnt tumor of the digestive system (1). Radiotherapy is the principal treatment for advanced ESCC (2). Clinically, enhancement computed tomography (CT), contrast enhanced magnetic resonance imaging (MRI) and barium meal is the main methods for evaluating the lesion and therapeutic effects (3).…”

Section: Introductionmentioning

confidence: 99%

DW‑MRI for esophageal squamous cell carcinoma, correlations between ADC values with histologic differentiation and VEGF expression: A retrospective study

Qing-xue

Wang

et al. 2019

Oncol Lett

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The aim of the present study was to assess the correlations between diffusion-weighted magnetic resonance imaging (DW-MRI) features with the histologic differentiation and the expression of vascular endothelial growth factor (VEGF) in esophageal squamous cell carcinoma (ESCC). A total of 52 patients with ESCC included in the present study received radiotherapy, and all patients underwent contrast enhanced MRI and DW-MRI prior to and following radiotherapy. The diffusion sensitivity coefficient ( b value) was set as 800 s/mm 2 . Apparent diffusion coefficient (ADC) values were automatically computed. VEGF expression was evaluated by immunohistochemical staining. The results demonstrated that the pathological grading of ESCC was positively correlated with ADC values ( r =0.635, P=0.0007), and the VEGF expression was inversely correlated with ADC values ( r =−0.321, P=0.008). However, no correlation was identified between the pathological grading and the VEGF expression ( r =0.178, P=0.284). All patients were categorized as complete response (CR) or partial response (PR) and the ADC values were increased significantly following radiotherapy. The mean ADC values in the CR group were higher than the PR group prior to radiotherapy ( t =5.156, P=0.0004). Therefore, we concluded that the DWI with ADC value measurement may represent the grade of tumor histologic differentiation and the degree of VEGF expression, and may also serve as a useful marker to predict radiotherapy and anti-VEGF response in ESCC. ADC value may be a substitution for assessing tumor angiogenesis and novel prognostic factor and contribute to the treatment of ESCC.

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Section: Introductionmentioning

confidence: 99%

DW‑MRI for esophageal squamous cell carcinoma, correlations between ADC values with histologic differentiation and VEGF expression: A retrospective study

Qing-xue

Wang

et al. 2019

Oncol Lett

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“…In ESAC, immunohistochemistry (IHC) analyses have shown that TRPM7 protein was expressed in the cytoplasm of carcinoma cells while not detected in the non-cancerous esophageal epithelia. High TRPM7 staining was associated with better 5-year survival in patients with ESAC [73] (Table 1). In PDAC patients, TRPM7 protein was overexpressed in cancerous tissues when compared to normal adjacent tissues [74][75][76][77].…”

Section: Analysis Of the Literaturementioning

confidence: 99%

“…As mentioned above, TRPM7 overexpression has been proposed as an independent good prognosis biomarker in ESAC. In the TE5 human ESAC cell line, TRPM7 silencing by siRNA enhances cell proliferation as well as migration and invasion [73]. Although the molecular mechanisms involved in TRPM7-mediated ESAC cell proliferation, migration and invasion are far from being fully elucidated, TRPM7 channel expression may prevent the oncogenic properties of ESAC cells.…”

Section: Regulation Of Digestive Cancer Cell Fates By Magnesium Transportersmentioning

confidence: 99%

Mg2+ Transporters in Digestive Cancers

et al. 2021

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Despite magnesium (Mg2+) representing the second most abundant cation in the cell, its role in cellular physiology and pathology is far from being elucidated. Mg2+ homeostasis is regulated by Mg2+ transporters including Mitochondrial RNA Splicing Protein 2 (MRS2), Transient Receptor Potential Cation Channel Subfamily M, Member 6/7 (TRPM6/7), Magnesium Transporter 1 (MAGT1), Solute Carrier Family 41 Member 1 (SCL41A1), and Cyclin and CBS Domain Divalent Metal Cation Transport Mediator (CNNM) proteins. Recent data show that Mg2+ transporters may regulate several cancer cell hallmarks. In this review, we describe the expression of Mg2+ transporters in digestive cancers, the most common and deadliest malignancies worldwide. Moreover, Mg2+ transporters’ expression, correlation and impact on patient overall and disease-free survival is analyzed using Genotype Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) datasets. Finally, we discuss the role of these Mg2+ transporters in the regulation of cancer cell fates and oncogenic signaling pathways.

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“…The different functions of hub genes have been involved in several cancers in previous studies, such as pancreatic cancer [37], bladder cancer [38], esophageal squamous cell carcinoma [39], and non-small cell lung carcinoma [40], especially in glioma [41]. The purpose of this study was to explore the functions of TRP family genes in gliomas.…”

Section: Amplification Mutation and Deletion Of Hub Genes In Gliomamentioning

confidence: 99%

TRP Family Genes Are Differently Expressed and Correlated with Immune Response in Glioma

Fang

Liu

et al. 2022

Brain Sciences

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(1) Background: glioma is the most prevalent primary tumor of the human central nervous system and accompanies extremely poor prognosis in patients. The transient receptor potential (TRP) channels family consists of six different families, which are closely associated with cancer cell proliferation, differentiation, migration, and invasion. TRP family genes play an essential role in the development of tumors. Nevertheless, the function of these genes in gliomas is not fully understood. (2) Methods: we analyze the gene expression data of 28 TRP family genes in glioma patients through bioinformatic analysis. (3) Results: the study showed the aberrations of TRP family genes were correlated to prognosis in glioma. Then, we set enrichment analysis and selected 10 hub genes that may play an important role in glioma. Meanwhile, the expression of 10 hub genes was further established according to different grades, survival time, IDH mutation status, and 1p/19q codeletion status. We found that TRPC1, TRPC3, TRPC4, TRPC5, TRPC6, MCOLN1, MCOLN2, and MCOLN3 were significantly correlated to the prognosis in glioma patients. Furthermore, we illustrated that the expression of hub genes was associated with immune activation and immunoregulators (immunoinhibitors, immunostimulators, and MHC molecules) in glioma. (4) Conclusions: we proved that TRP family genes are promising immunotherapeutic targets and potential clinical biomarkers in patients with glioma.

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Transient Receptor Potential Melastatin 7 as an Independent Prognostic Factor in Human Esophageal Squamous Cell Carcinoma

Cited by 20 publications

References 27 publications

DW‑MRI for esophageal squamous cell carcinoma, correlations between ADC values with histologic differentiation and VEGF expression: A retrospective study

DW‑MRI for esophageal squamous cell carcinoma, correlations between ADC values with histologic differentiation and VEGF expression: A retrospective study

Mg2+ Transporters in Digestive Cancers

TRP Family Genes Are Differently Expressed and Correlated with Immune Response in Glioma

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