Transient Receptor Potential (TRP) channels in T cells

Bertin, Samuel

doi:10.1007/s00281-015-0535-z

Cited by 39 publications

(38 citation statements)

References 123 publications

(216 reference statements)

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“…Several TRP channels are functionally expressed in the immune cells including lymphocytes, monocytes and macrophages 19 , 20 . Several TRP channels are also expressed on leukocytes, but the functional roles of these channels are still unclear.…”

Section: Discussionmentioning

confidence: 99%

Leukocyte TRP channel gene expressions in patients with non-valvular atrial fibrillation

Düzen

Yavuz

Vuruşkan

et al. 2017

Sci Rep

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Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and is a major cause of morbidity and mortality. The upregulation of TRP channels is believed to mediate the progression of electrical remodelling and the arrhythmogenesis of the diseased heart. However, there is limited data about the contribution of the TRP channels to development of AF. The aim of this study was to investigate leukocyte TRP channels gene expressions in non-valvular atrial fibrillation (NVAF) patients. The study included 47 NVAF patients and 47 sex and age matched controls. mRNA was extracted from blood samples, and real-time polymerase chain reaction was performed for gene expressions by using a dynamic array system. Low levels of TRP channel expressions in the controls were markedly potentiated in NVAF group. We observed marked increases in MCOLN1 (TRPML1), MCOLN2 (TRPML2), MCOLN3 (TRPML3), TRPA1, TRPM1, TRPM2, TRPM3, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8, TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, TRPC7, TRPV1, TRPV2, TRPV3, TRPV4, TRPV5, TRPV6, and PKD2 (TRPP2) gene expressions in NVAF patients (P < 0.05). However, there was no change in PKD1 (TRPP1) gene expression. This is the first study to provide evidence that elevated gene expressions of TRP channels are associated with the pathogenesis of NVAF.

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Section: Discussionmentioning

confidence: 99%

Leukocyte TRP channel gene expressions in patients with non-valvular atrial fibrillation

Düzen

Yavuz

Vuruşkan

et al. 2017

Sci Rep

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“…Also, TRP channels are able to modulate the function of immune cells, e.g. CD4+ T cells [27,28]. This review aims to provide an overview of what is currently known about the role of three TRP channels (TRPA1, TRPV1 and TRPV4) in the gut, their link with the immune system and their implications in inflammatory diseases of the intestine such as IBD.…”

Section: Introductionmentioning

confidence: 99%

Transient Receptor Potential Channels in Intestinal Inflammation: What Is the Impact of Cigarette Smoking?

Allais

Smet²,

Verschuere³

et al. 2016

Pathobiology

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Inflammatory bowel disease (IBD) is characterized by severe gastrointestinal inflammation and results from a complex interplay between genetic and environmental factors. IBD includes two prominent subtypes: Crohn's disease (CD) and ulcerative colitis (UC). One of the main risk factors for the development of CD is cigarette smoking, while UC is rather a disease of ex-smokers. To date, many of the mechanisms underlying the immune imbalance in IBD and the involvement of cigarette smoke (CS) are incompletely understood. Transient receptor potential (TRP) proteins are non-selective cation channels that, upon activation, lead to plasma membrane depolarization and, in general, to Ca²⁺ influx. TRP channels of the ankyrin and vanilloid family, expressed by sensory neurons in the central and enteric nervous systems, have been extensively studied in the context of intestinal inflammation. Moreover, recent advances made on the role of non-neuronal expressed TRP channels shed light on the involvement of epithelial cells in inflammatory processes. This review focuses on how CS may impact TRP channel function in intestinal inflammation. Firstly, we discuss the current knowledge on neuronal TRP channels, known to be linked to IBD, in health, immune homeostasis and intestinal inflammation. Subsequently, we address how TRP channels are activated by CS and its components in other organ systems and also hypothesize on the potential implications for CS-mediated TRP channel activation in gut inflammation.

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“…TRPA1, TRPV1 and several other TRP channels are also known to recognize and transduce signals coming from metabolites and environmental toxins, thereby playing an important role in the intrinsic control of a variety of gastrointestinal functions [ 58 ]. In addition, TRP channels are involved in the maintenance of blood flow, motor activity, secretory processes and mucosal homeostasis in the gastrointestinal tract and can also influence the function of immune cells such as CD4+ T-cells [ 45 , 59 ]. TRPV1 has also been found to play a role in the intestinal inflammation, pain and hyperalgesia [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

Role of TRP Channels in Shaping the Gut Microbiome

et al. 2020

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Transient receptor potential (TRP) channel family proteins are sensors for pain, which sense a variety of thermal and noxious chemicals. Sensory neurons innervating the gut abundantly express TRPA1 and TRPV1 channels and are in close proximity of gut microbes. Emerging evidence indicates a bi-directional gut–brain cross-talk in several entero-neuronal pathologies; however, the direct evidence of TRP channels interacting with gut microbial populations is lacking. Herein, we examine whether and how the knockout (KO) of TRPA1 and TRPV1 channels individually or combined TRPA1/V1 double-knockout (dKO) impacts the gut microbiome in mice. We detect distinct microbiome clusters among the three KO mouse models versus wild-type (WT) mice. All three TRP-KO models have reduced microbial diversity, harbor higher abundance of Bacteroidetes, and a reduced proportion of Firmicutes. Specifically distinct arrays in the KO models are determined mainly by S24-7, Bacteroidaceae, Clostridiales, Prevotellaceae, Helicobacteriaceae, Rikenellaceae, and Ruminococcaceae. A1KO mice have lower Prevotella, Desulfovibrio, Bacteroides, Helicobacter and higher Rikenellaceae and Tenericutes; V1KO mice demonstrate higher Ruminococcaceae, Lachnospiraceae, Ruminococcus, Desulfovibrio and Mucispirillum; and A1V1dKO mice exhibit higher Bacteroidetes, Bacteroides and S24-7 and lower Firmicutes, Ruminococcaceae, Oscillospira, Lactobacillus and Sutterella abundance. Furthermore, the abundance of taxa involved in biosynthesis of lipids and primary and secondary bile acids is higher while that of fatty acid biosynthesis-associated taxa is lower in all KO groups. To our knowledge, this is the first study demonstrating distinct gut microbiome signatures in TRPA1, V1 and dKO models and should facilitate prospective studies exploring novel diagnostic/ therapeutic modalities regarding the pathophysiology of TRP channel proteins.

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Transient Receptor Potential (TRP) channels in T cells

Cited by 39 publications

References 123 publications

Leukocyte TRP channel gene expressions in patients with non-valvular atrial fibrillation

Leukocyte TRP channel gene expressions in patients with non-valvular atrial fibrillation

Transient Receptor Potential Channels in Intestinal Inflammation: What Is the Impact of Cigarette Smoking?

Role of TRP Channels in Shaping the Gut Microbiome

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