Transient receptor potential V1 (TRPV1) modulates the therapeutic effects for comorbidity of pain and depression: The common molecular implication for electroacupuncture and omega-3 polyunsaturated fatty acids

Lin, Yi‐Wen; Chou, Ana Isabel Wu; Su, Huanxing; Su, Kuan‐Pin

doi:10.1016/j.bbi.2020.06.033

Cited by 41 publications

(47 citation statements)

References 36 publications

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“…Recent evidence implied that the central nervous system (CNS) plays an important role in the amplification of pain signals and the neurotransmitters associated with it [ 2 ]. Well-established fibromyalgia animal models can be produced by acidic saline injection into the gastrocnemius muscle [ 3 ], sound stress [ 4 ], and cold stress [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture reduces cold stress-induced pain through microglial inactivation and transient receptor potential V1 in mice

Liao

Lin

2021

Chin Med

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Background The treatment, and efficacy thereof, is considered to be inadequate with specificity to alleviation of Fibromyalgia and its associated pain. Fibromyalgia patients suffer from chronic and persistent widespread pain and generalized tenderness. Transient receptor potential V1 (TRPV1), which is reported as a Ca2+ permeable ion channel that can be activated by inflammation, is reported to be involved in the development of fibromyalgia pain. Methods The current study explored the TRPV1 channel functions as a noxious sensory input in mice cold stress model. It remains unknown whether electroacupuncture (EA) attenuates fibromyalgia pain or affects the TRPV1 pathway. Results We show that cold stress increases mechanical and thermal pain (day 7: mechanical: 1.69 ± 0.41 g; thermal: 4.68 ± 0.56 s), and that EA and Trpv1 deletion counter this increase. EA and Trpv1 deletion reduced the cold stress-induced increase in inflammatory mediators and TRPV1-related molecules in the hypothalamus, periaqueductal gray (PAG), and cerebellum of mice. Conclusions Our results imply that EA has an analgesic effect associated with TRPV1 downregulation. We provide novel evidence that these inflammatory mediators can modulate the TRPV1 signaling pathway and suggest new potential therapeutic targets for fibromyalgia pain.

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Section: Introductionmentioning

confidence: 99%

Electroacupuncture reduces cold stress-induced pain through microglial inactivation and transient receptor potential V1 in mice

Liao

Lin

2021

Chin Med

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“…Selective antagonists of TRPV1 can signi cantly reduce mechanical or thermal pain sensation [19,20]. Recently, we suggested that TRPV1 and related molecules were involved in the mice medial prefrontal cortex, hippocampus, and periaqueductal gray (PAG) following a cold stress challenge [5]. TRPV1 activation increases the protein kinases and mitogen-activated protein kinases (MAPK) that are crucial in several pain pathways.…”

Section: Introductionmentioning

confidence: 99%

“…Acupuncture is a more than 3000 years old practice that consists in inserting steel needles through the skin at speci c points (acupoint). Recent reports suggest that electroacupuncture (EA) can treat in ammatory pain, neuropathic pain, and bromyalgia pain in mice [3,5,13,16]. EA appears to relieve pain by increasing the release of endogenous opiates [26], dopamine [27], and adenosine [28].…”

Section: Introductionmentioning

confidence: 99%

“…Recent evidence implied that the central nervous system (CNS) plays an important role in the ampli cation of pain signals and the neurotransmitters associated with it [2]. Well-established bromyalgia animal models can be produced by acidic saline injection into the gastrocnemius muscle [3], sound stress [4], and cold stress [5].…”

Section: Introductionmentioning

confidence: 99%

“…EA appears to relieve pain by increasing the release of endogenous opiates [26], dopamine [27], and adenosine [28]. EA can also reduce cold stress pain (CSP) through downregulation of interleukins, TNFα, and IFN-γ in mice plasma [5]. Our previous article suggested that EA can reduce mechanical and thermal hyperalgesia in an in ammatory mouse model by attenuating the brain TRPV1 signaling pathway [15].…”

Section: Introductionmentioning

confidence: 99%

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Electroacupuncture Reduces Cold Stress-Induced Pain through Microglial Inactivation and Transient Receptor Potential V1 in Mice

Liao¹,

Lin²

2021

Preprint

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Background Fibromyalgia pain lacks objective parameters to measure treatment efficacy. Fibromyalgia patients suffer from chronic and persistent widespread pain and generalized tenderness. Transient receptor potential V1 (TRPV1), which is reported as a Ca2+ permeable ion channel that can be activated by inflammation, is reported to be involved in the development of fibromyalgia pain. Methods The current study explored the transient receptor potential vanilloid 1 (TRPV1) channel functions as a noxious sensory input in mice cold stress model. It remains unknown whether electroacupuncture (EA) attenuates fibromyalgia pain or affects the TRPV1 pathway. Results We show that cold stress increases mechanical and thermal pain (Day 7: mechanical: 1.69 ± 0.41 g; thermal: 4.68 ± 0.56 s), and that EA and Trpv1 deletion counter this increase. EA and Trpv1 deletion reduced the cold stress-induced increase in inflammatory mediators and TRPV1-related molecules in the hypothalamus, periaqueductal gray (PAG), and cerebellum of mice. Conclusions Our results imply that EA has an analgesic effect associated with TRPV1 downregulation. We provide novel evidence that these inflammatory mediators can modulate the TRPV1 signaling pathway and suggest new potential therapeutic targets for fibromyalgia pain.

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Placebo response varies between different types of sham acupuncture: A randomized double‐blind trial in neck pain patients

Zeng

Yan

Deng

et al. 2022

European Journal of Pain

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Background In prospective experimental studies of neck pain patients, it is difficult to determine whether responses to sham acupuncture differ from responses to real acupuncture due to the heterogeneous methodologies in control/sham interventions. Here we aim to compare the specific and nonspecific effects of electroacupuncture with four types of sham acupuncture. Methods In this double‐blind, sham‐controlled study, we randomly assigned 175 patients with neck pain to receive 10 sessions of electroacupuncture, shallow puncture, nonacupoint deep puncture, nonacupoint shallow puncture, or nonpenetration acupuncture. We used the Northwick Park Neck Pain Questionnaire (NPQ) as our primary outcome, and Short‐form McGill Pain Questionnaire, visual analog scale (VAS), and Pain Threshold as secondary outcomes to measure the changes from baseline to a 3‐month follow up. Results All groups, except nonacupoint shallow puncture, had significant improvement in all outcome measurements. Electroacupuncture only showed superior improvements than the shallow puncture, nonacupoint shallow puncture, and nonpenetration groups when compared using the NPQ and VAS scale (*p < 0.001). Interestingly, the nonacupoint shallow puncture produced even less placebo response than nonpenetration acupuncture. Conclusion Our study demonstrates the high variability of placebo response among different types of sham controls depending on the depth of needle insertion and the puncture location. An important implication of our results is nonacupoint deep puncture produced similar analgesic effects as electroacupuncture. Our study may shed a new light on the predominant underlying mechanisms among different types of sham acupuncture controls, which can help with interpreting the effect of acupuncture in other studies. Trial registration Chinese clinical trial registry (ChiCTR‐IOR‐15006886). Significance This study compared the observed specific and nonspecific analgesia effect in four different types of sham acupuncture stimulation with neck pain patients, assessed by four outcomes. Although all of the sham controls produced significant reduction in neck pain, electroacupuncture had superior significant improvement. Importantly, placebo responses differed significantly between the sham controls and responses were inconsistent according to different outcome assessments. This study emphasizes the importance of taking into consideration which sham control and method of outcome measurement were used in a pain research study when evaluating its results.

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Transient receptor potential V1 (TRPV1) modulates the therapeutic effects for comorbidity of pain and depression: The common molecular implication for electroacupuncture and omega-3 polyunsaturated fatty acids

Cited by 41 publications

References 36 publications

Electroacupuncture reduces cold stress-induced pain through microglial inactivation and transient receptor potential V1 in mice

Electroacupuncture reduces cold stress-induced pain through microglial inactivation and transient receptor potential V1 in mice

Electroacupuncture Reduces Cold Stress-Induced Pain through Microglial Inactivation and Transient Receptor Potential V1 in Mice

Placebo response varies between different types of sham acupuncture: A randomized double‐blind trial in neck pain patients

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