Transient recovery of epicardial and torso ST-segment ischemic signals during cardiac stress tests: A possible physiological mechanism

Zenger, Brian; Good, Wilson W.; Bergquist, Jake A; Rupp, Lindsay C; Perez, Maura; Stoddard, Gregory J.; Sharma, Vikas; MacLeod, Rob S.

doi:10.1016/j.jelectrocard.2021.07.007

Cited by 4 publications

(13 citation statements)

References 23 publications

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“…The current study may help guide future research on 6G or suitable derivatives for the effective prevention of As 2 O 3 -induced cardiotoxicity. Evidence has amassed that heart rate and ST height are frequently used as important indicators for normal cardiac functioning and that elevated heart rate and ST segment changes indicate damage of the myocardium ( Zenger et al, 2021 ). As 2 O 3 -induced myocardial injury is manifested by increased heart rate and ST-segment elevation ( Sonawane et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of 6-Gingerol on Cardiotoxicity Induced by Arsenic Trioxide Through AMPK/SIRT1/PGC-1α Signaling Pathway

et al. 2022

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Background and Objective: Arsenic trioxide (As2O3) induced cardiotoxicity to limit the clinical applications of the effective anticancer agent. 6-Gingerol (6G) is the main active ingredient of ginger, a food with many health benefits. The present study aims to investigate the potential pharmacological mechanisms of 6G on As2O3-induced myocardial injury.Methods and Results: Fifty KunMing mice were divided into five groups (n = 10) receiving: 1) physiological saline; 2) 6G (20 mg/kg) alone; 3) As2O3 (5 mg/kg); 4) 6G (10 mg/kg) and As2O3 (5 mg/kg); 5) 6G (20 mg/kg) and As2O3 (5 mg/kg). 6G was given orally and As2O3 was given intraperitoneally once per day for seven consecutive days. Biochemical, histopathological, transmission electron microscopy, ELISA, and western blotting analyses were then performed. Based on the resultant data, As2O3 was found to induce cardiotoxicity in mice. 6G significantly ameliorated As2O3-induced heart injury, histopathological changes, oxidative stress, myocardial mitochondrial damage, inflammation, and cardiomyocyte apoptosis, while reversed As2O3-induced inhibition of the AMPK/SIRT1/PGC-1α pathway.Conclusion: Our experimental results reveal that 6G effectively counteracts As2O3-induced cardiotoxicity including oxidative stress, inflammation and apoptosis, which might be attributed to its activation action on AMPK/SIRT1/PGC-1α signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Protective Effects of 6-Gingerol on Cardiotoxicity Induced by Arsenic Trioxide Through AMPK/SIRT1/PGC-1α Signaling Pathway

et al. 2022

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“…One goal of research applications of BSPM is on detecting and localizing ischemic cardiomyopathy through experimental models, cardiac stress testing, and acute MI events. Research from our group has focused on interpreting body surface potential changes during hyperacute episodes of ischemia [90,148,149]. Zenger et al recorded electrical activity on the torso surface using a large-animal experimental model while simultaneously inducing partial occlusion of a coronary artery and applying cardiac stress to create controlled acute myocardial ischemia.…”

Section: Direct Interpretation Of Bsp Signalsmentioning

confidence: 99%

“…Zenger et al recorded electrical activity on the torso surface using a large-animal experimental model while simultaneously inducing partial occlusion of a coronary artery and applying cardiac stress to create controlled acute myocardial ischemia. We have used these experimental recordings to explain complex physiological differences between various types of cardiac stressors, e.g., pharmacological versus exercise cardiac stress [148]. Furthermore, we identified a complex epicardial shielding phenomenon of ischemic potentials visible within the heart that propagated only partially to the torso surface [149].…”

Section: Direct Interpretation Of Bsp Signalsmentioning

confidence: 99%

Body Surface Potential Mapping: Contemporary Applications and Future Perspectives

Bergquist

Rupp

Zenger

et al. 2021

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Body surface potential mapping (BSPM) is a noninvasive modality to assess cardiac bioelectric activity with a rich history of practical applications for both research and clinical investigation. BSPM provides comprehensive acquisition of bioelectric signals across the entire thorax, allowing for more complex and extensive analysis than the standard electrocardiogram (ECG). Despite its advantages, BSPM is not a common clinical tool. BSPM does, however, serve as a valuable research tool and as an input for other modes of analysis such as electrocardiographic imaging and, more recently, machine learning and artificial intelligence. In this report, we examine contemporary uses of BSPM, and provide an assessment of its future prospects in both clinical and research environments. We assess the state of the art of BSPM implementations and explore modern applications of advanced modeling and statistical analysis of BSPM data. We predict that BSPM will continue to be a valuable research tool, and will find clinical utility at the intersection of computational modeling approaches and artificial intelligence.

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“…Historically, experimental models of whole-body cardiac electrophysiology were complex and resource intensive; in return for this investment, such models have provided valuable data to understand human electrophysiology ( Spach et al., 1977 ; Dosdall et al., 2013 ; Bear et al., 2018 ; Zenger et al., 2021a ; Zenger et al., 2021b ). Whole-body experimental models have been used to examine the development ( Li et al., 2001 ; Neuberger et al., 2005 ) and treatment modalities ( Calzolari et al., 2017 ; Solimene et al., 2019 ; Koruth et al., 2020 ) for atrial fibrillation (AF), including the seminal hypothesis “AF begets AF” ( Wijffels et al., 1968 ).…”

Section: Introductionmentioning

confidence: 99%

“…Large-scale experimental models have been used to test and validate novel imaging and electrical localization techniques, including electrocardiographic imaging (ECGI) ( Ramanathan et al., 2006 ; Bear et al., 2018 ; Cluitmans et al., 2018 ; Cuculich and Robinson, 2018 ; Grace et al., 2019 ; Bergquist et al., 2021 ). Furthermore, animal models have enhanced our understanding of cardiac signals that develop during acute myocardial ischemia and how these signals change in various cardiac stress circumstances ( Aras et al., 2011a ; Aras et al., 2016 ; Zenger et al., 2021a ; Zenger et al., 2021b ; Good et al., 2021 ). Animal experiments play many key roles in exploring mechanisms and often in providing behaviors and parameters included in subsequent numerical and computer modeling ( Plank et al., 2008 ; Quinn et al., 2011 ; Prakosa et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Tipping the scales of understanding: An engineering approach to design and implement whole-body cardiac electrophysiology experimental models

Zenger

Bergquist²,

Busatto³

et al. 2023

Front. Physiol.

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The study of cardiac electrophysiology is built on experimental models that span all scales, from ion channels to whole-body preparations. Novel discoveries made at each scale have contributed to our fundamental understanding of human cardiac electrophysiology, which informs clinicians as they detect, diagnose, and treat complex cardiac pathologies. This expert review describes an engineering approach to developing experimental models that is applicable across scales. The review also outlines how we applied the approach to create a set of multiscale whole-body experimental models of cardiac electrophysiology, models that are driving new insights into the response of the myocardium to acute ischemia. Specifically, we propose that researchers must address three critical requirements to develop an effective experimental model: 1) how the experimental model replicates and maintains human physiological conditions, 2) how the interventions possible with the experimental model capture human pathophysiology, and 3) what signals need to be measured, at which levels of resolution and fidelity, and what are the resulting requirements of the measurement system and the access to the organs of interest. We will discuss these requirements in the context of two examples of whole-body experimental models, a closed chest in situ model of cardiac ischemia and an isolated-heart, torso-tank preparation, both of which we have developed over decades and used to gather valuable insights from hundreds of experiments.

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Transient recovery of epicardial and torso ST-segment ischemic signals during cardiac stress tests: A possible physiological mechanism

Cited by 4 publications

References 23 publications

Protective Effects of 6-Gingerol on Cardiotoxicity Induced by Arsenic Trioxide Through AMPK/SIRT1/PGC-1α Signaling Pathway

Protective Effects of 6-Gingerol on Cardiotoxicity Induced by Arsenic Trioxide Through AMPK/SIRT1/PGC-1α Signaling Pathway

Body Surface Potential Mapping: Contemporary Applications and Future Perspectives

Tipping the scales of understanding: An engineering approach to design and implement whole-body cardiac electrophysiology experimental models

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