TRANSIENT (REVERSIBLE) MALABSORPTION OF VITAMIN B12

Herbert, Victor

doi:10.1111/j.1365-2141.1969.tb01364.x

Cited by 23 publications

(2 citation statements)

References 60 publications

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“…All o f the elderly patients whose macrocytic anemia was related to a purely nutritional folate defi ciency had normal Schilling tests. Moreover, no vitamin B12 malabsorption was observed in the 5 patients from this group who had decreased vitamin B12 levels, even though this deficiency could in itself be responsible for the vitamin B12 malabsorption [31].…”

Section: Discussionmentioning

confidence: 73%

Effect of Folate Deficiency on Vitamin B12 Absorption

Cattan¹,

Bélaïche²,

Zittoun³

et al. 1982

Ann Nutr Metab

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In three different groups of patients presenting severe folate deficiency (purely nutritional folate deficiency, chronic alcoholism or various intestinal diseases), vitamin B₁₂ absorption has been tested by Schilling test in order to investigate the possible effect of folate deficiency on B₁₂ absorption. Following this study, it appears that folate deficiency in itself, even severe, cannot induce vitamin B₁₂ malabsorption, since in the first group, consisting of malnourished old people, the Schilling test was always normal even in those who presented a lowered B₁₂ serum level; in the group of patients with intestinal disease, the Schilling test was abnormal as expected in some patients; 3 alcoholics out of 12 presented a malabsorption of B₁₂ on the Schilling test; the followup of 2 of them exhibited complete correction after normal diet and alcohol suppression. Consequently, folate deficiency does not seem responsible for a secondary B₁₂ malabsorption unless another etiological factor is present, such as alcohol or ileopathy.

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Section: Discussionmentioning

confidence: 73%

Effect of Folate Deficiency on Vitamin B12 Absorption

Cattan¹,

Bélaïche²,

Zittoun³

et al. 1982

Ann Nutr Metab

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“…63,64 A reversible absorptive loss of ileal capacity was demonstrated in the case of VB 12 deficiency, and it was suggested that a depletion of VB 12 further impairs the absorption of VB 12. 65 The pouch design with use of a diverting loop ileostomy leads to temporary bypassing the terminal ileum of about a mean length of ≤120 cm (range, 45Some researchers212 cm, including the pouch). 2,5,29 Despite the fact that patients with terminal ileal exclusion less than 20 cm are not at risk of developing VB 12 deficiency, 58 the stasis of small bowel contents predis-poses to bacterial overgrowth in both the ileal reservoir and the more proximal ileum until closure of the loop ileostomy.…”

Section: Resultsmentioning

confidence: 99%

Prevalence and Outcome of Anemia After Restorative Proctocolectomy

M’Koma

Wise

Schwartz

et al. 2009

Diseases of the Colon &Amp; Rectum

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PURPOSE Iron and/or vitamin B12 deficiency anemias, which have adverse effects on patients’ quality of life, are commonly observed and often overlooked complications after restorative proctocolectomy. We performed a systematic review of publications on the prevalence of anemia as well as on the impact of anemia on a range of clinical, functional, quality of life, and economic outcomes in restorative proctocolectomy patients. This information is important to help healthcare providers through a comprehensive overview to increase awareness about a condition that could require therapy to improve patient healthcare and quality of life. METHODS We reviewed the English language publications on the incidence of anemia and its adverse effect after restorative proctocolectomy The United States National Library of Medicine database (MEDLINE), the Excerpta Medica database (EMBASE), the Cochran Library, and the Google® search engine were searched for published articles on the prevalence and impact of anemia in post-restorative proctocolectomy surgical patients. RESULTS The long-term complication most frequently described after RPC is pouchitis. Pouchitis is significantly associated with iron deficiency anemia caused by pouch mucosal bleeding. Other causes are insufficient and/or impaired iron absorption. It has also been observed, however, that restorative proctocolectomy patients with underlying familial adenomatous polyposis rarely develop pouchitis yet show higher rates of iron deficiency anemia compared to those patients with underlying ulcerative colitis. Other causes shown as independent risk factors for iron deficiency anemia in restorative proctocolectomy patients are malignancy, desmoid tumors, and J-pouch configuration. Vitamin B12 deficiency anemia is also common after restorative proctocolectomy. About one-third of restorative proctocolectomy patients show abnormal Schilling test and 5 percent have low referenced serum cobalamin. It has been observed that the degree resection of the terminal-ileum, malabsorption, bacterial overgrowth, and dietary factors are among the known causes of cobalamin deficiency. Folate deficiency has not been reported in restorative proctocolectomy patients. Describing restorative proctocolectomy surgery and its outcomes, in patients without anemia, the quality of life is reported excellent regardless of operative technique. CONCLUSIONS Anemia is not uncommon following restorative proctocolectomy and has been shown to have negative effects on the patient's quality of life and the economy and may substantially increase healthcare costs. The treatment of anemia and its underlying causes is important to improving clinical and economic outcomes.

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Absorption of Water-Soluble Vitamins

Matthews

1974

Intestinal Absorption

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TRANSIENT (REVERSIBLE) MALABSORPTION OF VITAMIN B₁₂

Cited by 23 publications

References 60 publications

Effect of Folate Deficiency on Vitamin B<sub>12</sub> Absorption

Effect of Folate Deficiency on Vitamin B<sub>12</sub> Absorption

Prevalence and Outcome of Anemia After Restorative Proctocolectomy

Absorption of Water-Soluble Vitamins

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