Transient selective factor X deficiency in a severely burned child

Jennes, Serge; Saidane, Ghuider; Fauville, Jean-Philippe; Ledoux, Michel; Colinet, Benoît

doi:10.1016/j.burns.2007.06.009

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Symptoms related to the factor X deficiency depend on its serum concentration – values between 1% and 10% are associated with minor bleeding, especially during surgical procedures, or, as was the case with our patient, on removal of a central intravenous catheter. Severe bleeding is described when values fall below 1% 9. In the present case, despite the absence of fever, significant inflammatory markers or positive blood cultures, an initial diagnosis of infection, was entertained.…”

Section: Discussionmentioning

confidence: 56%

“…The acquired form also appears sporadically in patients with respiratory mycoplasma infection, vitamin K deficiency/liver disease and during the use of certain medications (valproic acid, topical thrombin) 4–6. In paediatric burn victims, three cases of transient factor X deficiency are described: one due to the presence of an inhibitor,7 another associated with anti-cardiolipin antibody8 and the third apparently related to meropenem use 9. The pathogenesis and transient nature of this deficiency remain poorly understood.…”

Section: Introductionmentioning

confidence: 99%

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Acquired-transient factor X deficiency in a teenager with extensive burns

Mascarenhas

Eusébio²,

Freitas³

et al. 2011

Case Reports

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Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Acquired-transient factor X deficiency in a teenager with extensive burns

Mascarenhas

Eusébio²,

Freitas³

et al. 2011

Case Reports

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The Rise of Factor X Level in Blood Plasma of Patients at Severe Burn Injuries

Kozynets

Tsyhankov

Korolova

et al. 2021

Journal of Burn Care &Amp; Research

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This work is dedicated to the detection of imbalance between the pro- and anti-coagulant branches of hemostasis at severe burn injuries by evaluating the content or activity of individual clotting factors. To select the targets for accurate diagnostics we measured the concentrations of soluble fibrin monomeric complexes and fibrinogen, levels of total prothrombin, factor X, protein C and antithrombin III, and recorded the time of clotting in activated partial thromboplastin time and prothrombin time tests. Factor X level was increased in 26 % of patients on the first day after the burn and it rose further in 62 % patients on the 14 th day of recovery. Increasing factor X level is assumed to be a risk factor of thrombotic complications. We propose to use it as a marker of predisposition to thrombosis at severe burn injury.

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Hypocoagulation induced by broad-spectrum antibiotics in extensive burn patients

Liu

et al. 2019

Burns &Amp; Trauma

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Background Patients with extensive burns usually develop pro-coagulation soon after the injury if there is no sepsis occurred. We describe the case of an extensive burn adult suffering from hypocoagulation not related to sepsis, but secondary to antibiotic treatment. Case presentation Here, we report a case of an adult male patient suffering from flame burns of 45% total body surface area (40% full thickness) combined with inhalation injury. Hypocoagulopathy with soaring prolonged activated partial thromboplastin time value occurred on third week post-burn while systemic infection had been under control by application of broad-spectrum antibiotics. Investigations showed that not the infection but vitamin K-related coagulation factor deficiency were responsible for unexpected bleeding. However, supplemental vitamin K was not the key as we expected, which prompted us trying to decode the underlying cause of coagulation disturbance in this patient and pick out the most effective treatment for live-saving. After the withdrawal of highly suspected broad-spectrum antibiotic, Meropenem®, disturbed vitamin K related coagulation factors gradually restored to their optimal levels so as to maintain normal coagulation status. Therefore, surgical procedures without further risk of bleeding could be carried out in time for wound recovery. The patient was discharged on post-burn day 67 and transferred to a secondary hospital for his rehabilitation. Conclusion Hypocoagulopathy may be devoted to different reasons other than sepsis in extensive burns. Early recognition of the cause for coagulation disturbance is critical to make appropriate treatment and save patients’ lives. This case illustrated the importance of unveiling the mist cause for coagulation disturbance occurred in extensive burn patient, which paved the way for optimal life-saving treatments. And we also recommend burn surgeons to be alerted to antibiotic-induced vitamin K deficiency-related coagulopathy among critical burn patients.

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Transient selective factor X deficiency in a severely burned child

Cited by 3 publications

References 18 publications

Acquired-transient factor X deficiency in a teenager with extensive burns

Acquired-transient factor X deficiency in a teenager with extensive burns

The Rise of Factor X Level in Blood Plasma of Patients at Severe Burn Injuries

Hypocoagulation induced by broad-spectrum antibiotics in extensive burn patients

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