Transient severe precapillary pulmonary hypertension caused by eosinophilic granulomatosis with polyangiitis in a patient diagnosed with asthma

Abstract

Although asthma is a common pulmonary disease, it rarely leads to pulmonary hypertension (PH). We report an 80-year-old female urgently hospitalized due to symptoms of acute heart failure. Her comorbidities included asthma confirmed by spirometry for at least previous 10 years, systemic hypertension and prediabetes. Despite various modifications of pharmacotherapy, asthma has never been satisfactory controlled.On admission, she was dyspneic, with prominent peripheral edema. Laboratory tests showed significant eosinophilia (EBC 9.0/L; reference range <0.3/L), N-terminal pro-brain natriuretic peptide (NT-proBNP 5881 pg/ml; reference range <450 ng/ml) and a stable level elevation of high-sensitive cardiac troponin T (hs-cTnT 670 ng/l; reference range <14 ng/l).