2018
DOI: 10.23736/s0390-5616.16.03406-8
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Transient spontaneous regression of brainstem glioblastoma

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“…Besides the above-mentioned possible role of dexamethasone and levetiracetam, the components of STUPP protocol may also have been a determinant in achieving the observed tumor disappearance: the event of complete response to chemoradiotherapy or temozolomide alone occurred rarely [23,24]. Given the rarity of spontaneous regression in GBM, which was reported as transient (like in our case) in only two other patients [25,26], the temporal relationship to BCG therapy suggests a possible causal relationship, but this cannot be confirmed based on a single case. Furthermore, bladder cancer recurrence followed by the development of two new lesions described here might be related to each other.…”
Section: Discussionmentioning
confidence: 56%
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“…Besides the above-mentioned possible role of dexamethasone and levetiracetam, the components of STUPP protocol may also have been a determinant in achieving the observed tumor disappearance: the event of complete response to chemoradiotherapy or temozolomide alone occurred rarely [23,24]. Given the rarity of spontaneous regression in GBM, which was reported as transient (like in our case) in only two other patients [25,26], the temporal relationship to BCG therapy suggests a possible causal relationship, but this cannot be confirmed based on a single case. Furthermore, bladder cancer recurrence followed by the development of two new lesions described here might be related to each other.…”
Section: Discussionmentioning
confidence: 56%
“…Indeed, surgical procedures (intended both as biopsy and resection of the primary tumor or metastases) may elicit immunologic surveillance through proinflammatory injuries leading up to complete regression of any residual macroscopic distant tumor [27]. This very rare phenomenon has been reported for a variety of tumor histologies, although not yet for gliomas [25,26,[28][29][30].…”
Section: Discussionmentioning
confidence: 99%