Transient superdiffusion of polydisperse vacuoles in highly motile amoeboid cells

Thapa, Samudrajit; Lukat, Nils; Selhuber‐Unkel, Christine; Cherstvy, Andrey G.; Metzler, Ralf

doi:10.1063/1.5086269

Cited by 39 publications

(29 citation statements)

References 109 publications

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“…At time scale 0.2 < t < 2 s, molecular motors make the growth of EMSD super-diffusive with the anomalous exponent α ∼ 1.26 ± 0.02 and the ensemble generalized diffusion coefficient D α ∼ 0.082 ± 0.002 µm 2 /s α . Similar behaviour was observed for the transport of micron-sized beads along microtubules [51] and endosomes filled with labeled nonviral DNA-containing polyplexes ranging from 100 to 200 nm in diameter [10] and for single cell trajectories [52]. At longer time scales (t > 2 s), the EMSD become sub-diffusive (Fig.…”

Section: B Experimental Endosomal Trajectories Display Ergodic But An...supporting

confidence: 73%

Unravelling Heterogeneous Transport of Endosomes

Korabel¹,

Han²,

Taloni³

et al. 2021

Preprint

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A major open problem in biophysics is to understand the highly heterogeneous transport of many structures inside living cells, such as endosomes. We find that mathematically it is described by spatio-temporal heterogeneous fractional Brownian motion (hFBM) which is defined as FBM with a randomly switching anomalous exponent and random generalized diffusion coefficient. Using a comprehensive local analysis of a large ensemble of experimental endosome trajectories (> 10 5 ), we show that their motion is characterized by power-law probability distributions of displacements and displacement increments, exponential probability distributions of local anomalous exponents and power-law probability distributions of local generalized diffusion coefficients of endosomes which are crucial ingredients of spatio-temporal hFBM. The increased sensitivity of deep learning neural networks for FBM characterisation corroborates the development of this multi-fractal analysis. Our findings are an important step in understanding endosome transport. We also provide a powerful tool for studying other heterogeneous cellular processes.

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Section: B Experimental Endosomal Trajectories Display Ergodic But An...supporting

confidence: 73%

Unravelling Heterogeneous Transport of Endosomes

Korabel¹,

Han²,

Taloni³

et al. 2021

Preprint

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“…Lastly, our methods must be applied to the recent study on the static detection of particle positions [18]. It is important to note that the particle size considered in our simulations was infi nitesimal.…”

Section: Discussionmentioning

confidence: 99%

Fast algorithms for particle searching and positioning by cell registration and area comparison

Ogami¹

2021

Trends in Computer Science and Information Technology

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Background Cartesian Grid Position; AC: Area Comparison the computational domain into various rectangular regions of Cartesian grid systems with a small number of triangular elements. The particle trajectory is tracked by searching the rectangular regions fi rst and then the triangular elements. This method also improved calculation effi ciency. However, the grid cell system is limited to a triangular grid system, and searching grids in small areas can still be time-consuming.

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“…In the recent past, a number of experimental and theoretical studies have been carried out to investigate the dynamics of the self-propelled species in crowded and complex environments [17][18][19][20][21][22][23][24][25] . Recent experimental and theoretical studies reported enhanced rotation of a self-propelled Janus particle in polymer solution 6,22 .…”

Section: Introductionmentioning

confidence: 99%

Chemically symmetric and asymmetric self-driven rigid dumbbells in 2D polymer gel

Kumar,

Theeyancheri,

Chakrabarti

2021

Preprint

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We employ computer simulations to unveil the translational and rotational dynamics of the self-driven chemically symmetric and asymmetric rigid dumbbells in two-dimensional polymer gel. Our results show that activity or the selfpropulsion always enhances the dynamics of the dumbbells. Making the self-propelled dumbbell chemically asymmetric leads to further enhancement in dynamics. Additionally, the direction of self-propulsion is a key factor for the chemically asymmetric dumbbells, where self-propulsion towards the non-sticky half of the dumbbell results in faster translational and rotational dynamics compare to the case with the self-propulsion towards the sticky half of the dumbbell. Our analyses show that both the symmetric and asymmetric passive rigid dumbbells get trapped inside the mesh of the polymer gel, but the chemical asymmetry always facilitates mesh to mesh motion of the dumbbell and it is even more pronounced when the dumbbell is self-propelled. This results multiple peaks in the van Hove function with increasing self-propulsion. In a nutshell, we believe that our in silico study can guide the researchers design efficient artificial microswimmers possessing potential applications in site-specific delivery.

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Transient superdiffusion of polydisperse vacuoles in highly motile amoeboid cells

Cited by 39 publications

References 109 publications

Unravelling Heterogeneous Transport of Endosomes

Unravelling Heterogeneous Transport of Endosomes

Fast algorithms for particle searching and positioning by cell registration and area comparison

Chemically symmetric and asymmetric self-driven rigid dumbbells in 2D polymer gel

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