2020
DOI: 10.1101/2020.10.30.358697
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Transient systemic inflammation in adult male mice results in underweight progeny

Abstract: Problem: While the testes represent an immune privileged organ, there is evidence that systemic inflammation is accompanied by local inflammatory responses. We therefore examined if transient systemic inflammation caused any inflammatory and functional consequences in murine testes. Method of Study: Using a single systemic administration of Toll-like receptor (TLR) agonists [lipopolysaccharide (LPS) or peptidoglycan (PG) or polyinosinic-polycytidylic acid (polyIC)] in young adult male mice, we assessed testicu… Show more

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