This review article discusses the current role of ultrasound in interventional spine practice as both a diagnostic tool and as a modality for image guidance with procedures. Epidemiology of spine pain, the emergence of ultrasound, advantages and disadvantages of ultrasound in comparison to other image modalities are discussed. Recent selected published articles pertaining to the role of ultrasound in the guidance of spinal interventional procedures are reviewed. The potential for the use of ultrasound with spine procedures is discussed as well as further evaluation of its cost-effectiveness, accuracy, safety, and efficacy when compared to the current standards of practice.