Transient visual loss: Transient lesion in the splenium of the corpus callosum

Günaydın, Mücahit; Ozsahin, Faruk

doi:10.1016/j.tjem.2017.12.004

Cited by 6 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Irrespective of its independence from the splenium, the tapetum could be transferring visual information to the visual cortex as shown by a diffusion study that placed a seed in the splenium of the corpus callosum (Caspers et al 2015). Interestingly, a patient with a transient splenium lesion, near the tapetum, has been reported to have a transient visual field loss with no other neurological symptoms (Gunaydin and Ozsahin 2018).…”

Section: Discussionmentioning

confidence: 99%

The visual white matter connecting human area prostriata and the thalamus is retinotopically organized

et al. 2020

View full text Add to dashboard Cite

The human visual system is capable of processing visual information from fovea to the far peripheral visual field. Recent fMRI studies have shown a full and detailed retinotopic map in area prostriata, located ventro-dorsally and anterior to the calcarine sulcus along the parieto-occipital sulcus with strong preference for peripheral and wide-field stimulation. Here, we report the anatomical pattern of white matter connections between area prostriata and the thalamus encompassing the lateral geniculate nucleus (LGN). To this end, we developed and utilized an automated pipeline comprising a series of Apps that run openly on the cloud computing platform brainlife.io to analyse 139 subjects of the Human Connectome Project (HCP). We observe a continuous and extended bundle of white matter fibers from which two subcomponents can be extracted: one passing ventrally parallel to the optic radiations (OR) and another passing dorsally circumventing the lateral ventricle. Interestingly, the loop travelling dorsally connects the thalamus with the central visual field representation of prostriata located anteriorly, while the other loop travelling more ventrally connects the LGN with the more peripheral visual field representation located posteriorly. We then analyse an additional cohort of 10 HCP subjects using a manual plane extraction method outside brainlife.io to study the relationship between the two extracted white matter subcomponents and eccentricity, myelin and cortical thickness gradients within prostriata. Our results are consistent with a retinotopic segregation recently demonstrated in the OR, connecting the LGN and V1 in humans and reveal for the first time a retinotopic segregation regarding the trajectory of a fiber bundle between the thalamus and an associative visual area.

show abstract

Section: Discussionmentioning

confidence: 99%

The visual white matter connecting human area prostriata and the thalamus is retinotopically organized

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In their study that focused on the etiology of splenial lesions, Balcik et al [26] reported 5 infection-related cases (3 tuberculosis meningitis and 2 viral encephalitis), where the outcomes of the patients were not stated. There are also a few case reports from our country on the adult population [27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Radiologic and clinical features of infection related cytotoxic lesions of corpus callosum splenium in adults

İkidağ¹

2021

Journal of Surgery and Medicine

View full text Add to dashboard Cite

Background/Aim: The cytotoxic lesion of corpus callosum splenium (CLCCS) is a clinical-radiologic syndrome that typically manifests in children. It is characterized by restricted diffusion in the splenium of the corpus callosum on magnetic resonance imaging, and accompanying symptoms of encephalopathy. There are a few case reports regarding the adult population in the literature, and only a couple of these are related to febrile illness in adults. We aimed to evaluate the clinical and the radiologic characteristics of infections related to CLCCS in adults. Methods: For this case series study, we reviewed the MRI examinations that were performed in our hospital between 2014 and 2019 to identify cases with corpus callosum splenium lesions related with febrile diseases in adults. We excluded the cases with demyelinating diseases, trauma, arterial or venous occlusive diseases, metabolic-toxic diseases, and posterior reversible encephalopathy syndrome (PRES), patients who had alcohol or drug abuse, or known malignancies. The admission dates, symptoms within the prodromal period, physical and laboratory findings, electroencephalograms, MRI features, medications and patient outcomes were recorded. Corpus callosum involvement on MRI was classified as Type 1 if lesions were limited to splenium, and Type 2 if pericallosal white matter extension was present. Results: Seven patients (four males, three females, and ages ranging from 18 to 33 years with a mean of 26.4 years) were included in the study. All patients experienced prodromal symptoms such as fever (n=7), nausea (n=5), vomiting (n=4), diarrhea (n=4) and abdominal discomfort (n=3). Neurological symptoms included drowsiness (n=4), speech disorder (n=2), impairment of consciousness (n=4), lower extremity weakness (n=2), and seizures (n=1). Neurological examination revealed confusion (n=4), nuchal rigidity (n=2), and ataxia (n=2). In one patient, the blood culture was positive for Staphylococcus epidermidis, and the stool culture was positive for Enterococcus species. MRI findings of all patients revealed Type 1 oval (n=4) or round (n=3) shaped corpus callosum splenium lesions that appeared hyperintense on T2 and FLAIR images with diffusion restriction. None of our patients had band-like Type 1 or Type 2 lesions. Clinical relief was observed in 2 days in six patients, however, rapid clinical deterioration resulting in death occurred in one patient. Conclusion:The leading symptoms in adults are fever and gastrointestinal disturbances including, nausea, vomiting, and diarrhea, while neurological examinations mostly reveal confusion, nuchal rigidity, and ataxia. In adult patients, restricted diffusion on MRI is usually limited to splenium, and pericallosal white matter is usually not involved. Mostly encountered in autumn and winter, encephalitis/encephalopathy with diffusion restriction in the splenium of corpus callosum in an adult febrile patient usually has a good prognosis, although it may lead to severe outcomes, and even result with death. Clinicians should be aware...

show abstract

“…A 24-year-old 3-month postpartum woman had multiple episodes of bilateral painless vision loss ∼ 30 seconds in duration over 2 hours, with a CLOCC lesion on MRI and no other abnormalities on workup except an isolated fever. Her only active intervention included intravenous saline, and her symptoms and MRI lesion subsequently resolved (4). There is no clear hypothesis in the literature as to why a lesion in the corpus callosum might cause transient bilateral vision loss.…”

mentioning

confidence: 99%

Transient Bilateral Visual Loss as the Presenting Symptom of High-Altitude Ascent-Related Cytotoxic Lesion of the Corpus Callosum

Yang¹,

Raviskanthan²,

Mortensen³

et al. 2022

Journal of Neuro-Ophthalmology

View full text Add to dashboard Cite

Transient visual loss: Transient lesion in the splenium of the corpus callosum

Cited by 6 publications

References 4 publications

The visual white matter connecting human area prostriata and the thalamus is retinotopically organized

The visual white matter connecting human area prostriata and the thalamus is retinotopically organized

Radiologic and clinical features of infection related cytotoxic lesions of corpus callosum splenium in adults

Transient Bilateral Visual Loss as the Presenting Symptom of High-Altitude Ascent-Related Cytotoxic Lesion of the Corpus Callosum

Contact Info

Product

Resources

About