Transimpedance Amplifiers for Extremely High Sensitivity Impedance Measurements on Nanodevices

Ferrari, Giorgio; Gozzini, Fabio; Sampietro, Marco

doi:10.1007/978-1-4020-8944-2_11

Cited by 1 publication

(1 citation statement)

References 31 publications

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“…The analog front-end of this block is composed of a single-stage voltage feedback transimpedance amplifier (TIA) meant to collect and amplify the SiNW-bioFET drain-source current I DS , converting it at the TIA output into the voltage signal V TIAout [29]. The TIA is followed by a passive RC circuit meant to drive the Analog to Digital Converter marking the input of the PSD stage.…”

Section: B Signal Conditioningmentioning

confidence: 99%

System-Level Sensitivity Analysis of SiNW-bioFET-Based Biosensing Using Lock-In Amplification

et al. 2017

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Abstract-Although Silicon Nanowire biological Field-Effect Transistors (SiNW-bioFETs) have steadily demonstrated their ability to detect biological markers at ultra-low concentration, they have not yet translated into routine diagnostics applications. One of the challenges inherent to the technology is that it requires an instrumentation capable of recovering ultra-low signal variations from sensors usually designed and operated in a highly-resistive configuration. Often overlooked, the SiNWbioFET/instrument interactions are yet critical factors in determining overall system biodetection performances.Here, we carry out for the first time the system-level sensitivity analysis of a generic SiNW-bioFET model coupled to a custom-design instrument based on the lock-in amplifier. By investigating a large parametric space spanning over both sensor and instrumentation specifications, we demonstrate that systemwide investigations can be instrumental in identifying the design trade-offs that will ensure the lowest Limits-of-Detection. The generic character of our analytical model allows us to elaborate on the most general SiNW-bioFET/instrument interactions and their overall implications on detection performances. Our model can be adapted to better match specific sensor or instrument designs to either ensure that ultra-high sensitivity SiNW-bioFETs are coupled with an appropriately sensitive and noise-rejecting instrumentation, or to best tailor SiNW-bioFET design to the specifications of an existing instrument.

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Section: B Signal Conditioningmentioning

confidence: 99%