Transition Metal-Catalyzed C—H Oxidation Reactions

Abstract

Our recent progress in transition metal-catalyzed C-H oxidation reactions is summarized. The effect of catalysts, oxidants and solvents on the C-H bond oxidative cleavage reactions is described, and the mechanisms of these C-H oxidation reactions are also discussed.

Oxidative 1,2-carboamination of alkenes with alkyl nitriles and amines toward γ-amino alkyl nitriles

“…2c and for the detailed information, see Supplementary Fig. 39 ) 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 . Gratifyingly, product 4 were easily converted to 1,4-diamine 42 , γ -amino acid 43 and γ -amino amide 44 in good yields ( Fig.…”

“…Consequently, the mechanisms for the Ag 2 CO 3 -mediated 1,2-alkylamination reaction was proposed ( Fig. 3 ) 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 . Coordination of the nitrogen atom in MeCN 2a with AgCO 3 gives the intermediate A , which sequentially reacts with AgCO 3 to afford the AgCH 2 CN intermediate B and AgHCO 3 .…”

“…In recent years, the C–H oxidative functionalization reaction has attracted much attention due to its inherent features, such as high step economy and atom economy 1 2 3 4 5 6 37 38 39 40 41 . Typical transformations include the difunctionalization of alkenes with alkyl C( sp 3 )–H bonds 42 43 44 45 46 47 48 49 50 51 52 53 54 55 and the majority of which rely on the formation of a sp 3 -hybridized carbon-centred radical from the oxidative cleavage of the corresponding alkyl C( sp 3 )–H bond followed by addition across the C–C double bond 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 .…”

Progress in Organic Synthesis Reactions Catalyzed by Palladium Supported on Magnetic Nanoparticles

“…因此, 近年 来, 以二氧化硅修饰的磁性纳米粒子为催化剂载体已成 为研究的热点 [38] . [46] . 近年来, 磁性核壳介孔氧化硅作为一种新型功能材 料, 因其复合内核和壳层的功能独特的磁响应性、较大 的比表面积、较低的毒性、孔道的发散性以及表面可化 学修饰性等特点, 已在磁性酸性催化、C-C 偶联反应、 加氢催化和光催化等领域得到广泛的应用 [50] .…”

TBHP-Mediated C–H Thiolation of Tetrahydrofuran with Disulfides Promoted by Catalytic Amounts of Na2CO3

“…Synthetic methods to generate chemical bonds directly from at least one C-H bond under oxidative conditions represents state-of-art organic synthesis. [1][2][3][4][5][6][7][8] In the last few decades, an impressive number of efficient methodologies have been introduced to allow the connection of C(sp)-H, C(sp 2 )-H, and even C(sp 3 )-H bonds with functional groups. Despite impressive progress in the field, examples of the construction of C-S bonds using the C-H oxidative cross-coupling strategy are quite rare.…”