Transition‐Metal Catalyzed Coupling Reactions for the Synthesis of (Het)aryl Ketones: An Approach from their Synthesis to Biological Perspectives

Abstract

Synthetic protocols capable of incorporating acyl based functional moieties have been proved fruitful to develop variety of carbonyl containing organic molecules. Substituted‐aromatic ketones are important motifs in different natural products and biologically active pharmaceuticals. Substituted aromatic ketones based compounds have been proved effective as antioxidant, antiallergic, antimicrobial, antimitotic, anticholinergic, antiinflammatory, anticonvulsant, antipsychotic age, anticancer, antimicrobial, antimalarial, and antiviral agents, Transition metals are necessary part of modern catalytic systems for carbonylative transformations. Carbonylative coupling reaction involves direct introduction of carbonyl fragment for synthesis of biaryls, aryl/alkyl ketones through transition metals based catalytic systems. In this review, we have reported the synthesis of biaryls, aryl/alkyl ketones by using different feed stocks in presence of various transition metal catalysts.

Quantifying flattening distortion on the thermodynamics and kinetics of electron transfers of Cu(i) photoredox catalysts

“…Visible-light photoredox catalysis has revolutionized organic synthesis by enabling the activation of small molecules, transforming photonic energy into chemical energy. 1,2 In the last decade, it has been used in the synthesis of various industrially and medicinally relevant compounds, 3–8 as well as promoting different types of reactions such as C–C and C–heteroatom bond formation, 9–14 dehydrogenation, 15 C–H functionalization, 16,17 polyfluoroarylation, 18 atom transfer radical additions, 14,19 H 2 evolution, 20,21 and CO 2 reduction. 22…”