Transition-metal complex-catalyzed alkane functionalization

Tang, Xinxin; Huang, Zheng

doi:10.1360/n972018-00310

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Cited by 2 publications

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“…Synthesis of silicon-containing compounds has attracted considerable attention, owing to their broad applications in organic synthesis, medicinal chemistry and material science [1][2][3][4][5][6][7][8][9]. As alkenes' wide availability and stability, synthesis of organosilanes from alkenes is one of most important topics in the field of organosilane synthesis [2,10].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Ni/Cu catalyzed migratory arylsilylation of terminal olefins

Zhao

et al. 2021

Science Bulletin

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Section: Introductionmentioning

confidence: 99%

Synergistic Ni/Cu catalyzed migratory arylsilylation of terminal olefins

Zhao

et al. 2021

Science Bulletin

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Chiral NCN Pincer Iridium(III) Complexes with Bis(imidazolinyl)phenyl Ligands: Synthesis and Application in Enantioselective C–H Functionalization of Indoles with α-Aryl-α-diazoacetates

Zhu

Huang

et al. 2020

Organometallics

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A series of chiral NCN pincer iridium(III) complexes 2a−h with bis(imidazolinyl)phenyl ligands were synthesized via the central aryl C2−H bond activation of the 1,3-bis(2′-imidazolinyl)benzene ligands. The incorporation of a 5tert-butyl group into the central aryl ring of the ligands was found to markedly improve the efficiency of the desired C2-metalation, leading to an obvious enhancement in the yields of the Ir(III) complexes. Consequently, complexes with a tert-butyl group on the central aryl ring were obtained in 34−47% yields, whereas those without the group were produced in only 13−16% yields. All of the new complexes have been characterized by elemental analysis and 1 H and 13 C{ 1 H} NMR spectroscopy. In addition, the molecular structures of complexes 2c, 2d, and 2g′ have been determined by X-ray single-crystal diffraction. 2c and 2d are, indeed, the anticipated six-coordinate pincer Ir(III) complexes. In contrast, 2g′ is a coordinatively unsaturated five-coordinate pincer Ir(III) complex. The Ir(III) complexes were used as the catalysts for the asymmetric C−H insertion reaction of α-aryl-α-diazoacetates with N-protected indoles. With a catalyst loading of 3 mol % and in the presence of 6 mol % of NaBAr F , a variety of optically active indole derivatives bearing chiral functional groups at the C3 position were obtained in good yields with moderate to good enantioselectivities (up to 86% ee).

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Transition-metal complex-catalyzed alkane functionalization

Cited by 2 publications

References 63 publications

Synergistic Ni/Cu catalyzed migratory arylsilylation of terminal olefins

Synergistic Ni/Cu catalyzed migratory arylsilylation of terminal olefins

Chiral NCN Pincer Iridium(III) Complexes with Bis(imidazolinyl)phenyl Ligands: Synthesis and Application in Enantioselective C–H Functionalization of Indoles with α-Aryl-α-diazoacetates

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