Transition metal complexes of ligand 4-imino-3-[(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)diazenyl]-4H pyrimido[2,1-b][1,3]benzothiazol-2-ol containing benzothiazole moiety: Synthesis, spectroscopic characterization and biological evaluation

Rangappa, Maliyappa M.; Keshavayya, J.; Krishna, P. Murali; Rajesh, K.

doi:10.1016/j.inoche.2021.108524

Cited by 10 publications

(4 citation statements)

References 54 publications

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“…They were also used in biological applications including therapeutics and chemosensors. [13] On the other side, several metal complexes have been applied as potential chemotherapeutic, anti-inflammatory, neurological, antibacterial, and anticancer drugs in pharmaceutical chemistry as well as highly significant economic applications. [14][15][16] Furthermore, nanosized metal chelates have received rising attention as a result of their fantastic magnetic, optical, electrical, and catalytic characteristics, [17,18] and hence, such compounds are essentially applied in bioinorganic chemistry because of their high biological efficiency.…”

Section: Introductionmentioning

confidence: 99%

Nano‐synthesis, solid‐state structural characterization, and antimicrobial and anticancer assessment of new sulfafurazole azo dye‐based metal complexes for further pharmacological applications

Khedr

El‐Ghamry

El-Sayed

2021

Applied Organom Chemis

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A new azo dye ligand (abbreviated as H 3 L) derived from coupling of sulfafurazole diazonium salt with 2,4-dihydroxybenzaldehyde was prepared and characterized applying different spectroscopic and analytical techniques.The novel nanosized trivalent Cr and Fe alongside with divalent Mn, Co, Ni, and Cd complexes with H 3 L have been synthesized for further promising pharmaceutical uses. All complexes were totally characterized by investigating various analytical and spectral tools such as microanalysis, FT-IR, 1 H NMR, UV-Vis, powder XRD, and TEM spectra as well as magnetic moment and molar conductance measurements. Microanalysis, TGA, and conductance studies confirmed the formation of all metal complexes in 1:1 (L: M) molar ratio with covalent mode. The FT-IR and 1 H NMR investigation asserted the chelation of H 3 L to different metal ions through azo nitrogen and phenolic deprotonated hydroxy oxygen in the o-position. UV-Vis, ESR, and magnetic moment studies revealed octahedral geometry around Cr and Fe ions, whereas Mn, Co, Ni, and Cd complexes displayed tetrahedral configurations. XRD patterns and TEM images proved homogeneous distribution over the chelates surfaces and nanometric size of complexes particles. Molecular modeling was used to optimize the complexes' geometric structure showing good harmonity with the experimental results. The antifungal and antibacterial efficiencies were strongly enhanced upon complex formation. Cr(III) and Ni(II) complexes showed the strongest and promising anticancer activities (IC 50 = 7.64 and 6.99 μg/ml) among the tested compounds, whereas Cd(II) complex showed moderate anticancer efficiency (IC 50 = 12.10 μg/ml), compared with the 5-fluorouracil (applied standard drug) with IC 50 = 6.44 μg/ ml.

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Section: Introductionmentioning

confidence: 99%

Nano‐synthesis, solid‐state structural characterization, and antimicrobial and anticancer assessment of new sulfafurazole azo dye‐based metal complexes for further pharmacological applications

Khedr

El‐Ghamry

El-Sayed

2021

Applied Organom Chemis

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“…The complex showed anticancer activity against A549, and K562 with an IC 50 value of 19.28 and 23.50 μM cell lines (Figure 18). [70] The synthesis of mitochondria-targeted cyclometalated Ir (III) complex 24 (Figure 19) was synthesized and evaluated against cisplatin-resistant A549R cancer cell lines. The complex 24 showed oncosis mediated non-apoptotic programmed cell death by activating porimin and calpain oncosisspecific proteins.…”

Section: Benzothiazole As Anticancer Agentsmentioning

confidence: 99%

Anticancer Potential of the S‐Heterocyclic Ring Containing Drugs and its Bioactivation to Reactive Metabolites

Maji,

Debnath,

Panda

et al. 2024

Chemistry & Biodiversity

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Sulfur‐containing heterocyclic derivatives have been disclosed for binding with a wide range of cancer‐specific protein targets. Various interesting derivatives of sulfur‐containing heterocyclics such as benzothiazole, thiazole, thiophene, thiazolidinedione, benzothiophene, and phenothiazine, etc have been shown to inhibit diverse signaling pathways implicated in cancer. Significant progress has also been made in molecular targeted therapy against specific enzymes such as kinase receptors due to potential binding interactions inside the ATP pocket. Sulfur‐containing heterocyclic ring metal complexes i.e., benzothiazole, thiazole, thiophene, benzothiophene and phenothiazines are among the most promising active anticancer compounds. However, sulfur heteroaromatic rings, particularly thiophene, are of high structural alert due to their metabolism to reactive metabolites. The mere presence of a structural alert itself does not determine compound toxicity therefore, this review focuses on some specific findings that shed light on factors influencing the toxicity. In the current review, synthetic strategies of introducing the sulfur core ring in the synthesized derivatives are discussed with their structure‐activity relationships to enhance our understanding of toxicity mechanisms and develop safer therapeutic options. The sulfur‐containing marketed anticancer drugs included in this review direct the synthesis of novel compounds and will help in the development of potent, safer sulfur‐based anticancer drugs in near future.

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“…to discovery out the degree of its cleanliness. and the flaws in the mineral construction when changing the ligand into its metal complex There are certain deflection mountains for which a appraisal happens for the next reasons: Micro strain, such as the absence of mineral frame distortion, and mineral criticizing happens As a consequence of the misrepresentations that happen in the mineral and the mineral scope area ((Domain size of the Crystal and Distribution of domain)) (22,23) . The Debye-Scherr reckoning was also used Debye-Scherer to compute the mineral size of Leyland (HL H) and its metallic complex as follows (24) .…”

Section: X-ray Diffraction Study (Xrd)mentioning

confidence: 99%

Preparation, spectroscopic characterization and study of biological activity as anticancer of some compounds using a new azo-Schiff base ligand (N,N,O) derived from 2-amino-5-methyl thiazol

Al-Adilee

Hassan

2022

ijhs

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The biological activity of the Co(III) complex of azo-Schiff bases derived from 2-amino-5-methylthiazole azo-Schiff bases was studied. Elementary examines, attractive instant volumes, spectroscopy (IR, electronic, 1 H NMR, and XRD), then thermogravimetric investigations described the azo-Schiff bases and their mineral complexes. For the cobalt complex, an octahedral geometry has been proposed. Thermal and infrared data of the mineral complexes confirmed the presence of the collected water. Schiff bases and mineral complexes have been tested for their anti-cancer properties

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Transition metal complexes of ligand 4-imino-3-[(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)diazenyl]-4H pyrimido[2,1-b][1,3]benzothiazol-2-ol containing benzothiazole moiety: Synthesis, spectroscopic characterization and biological evaluation

Cited by 10 publications

References 54 publications

Nano‐synthesis, solid‐state structural characterization, and antimicrobial and anticancer assessment of new sulfafurazole azo dye‐based metal complexes for further pharmacological applications

Nano‐synthesis, solid‐state structural characterization, and antimicrobial and anticancer assessment of new sulfafurazole azo dye‐based metal complexes for further pharmacological applications

Anticancer Potential of the S‐Heterocyclic Ring Containing Drugs and its Bioactivation to Reactive Metabolites

Preparation, spectroscopic characterization and study of biological activity as anticancer of some compounds using a new azo-Schiff base ligand (N,N,O) derived from 2-amino-5-methyl thiazol

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