Transition Metal Complexes of Thiosemicarbazides, Thiocarbohydrazides, and Their Corresponding Carbazones with Cu(I), Cu(II), Co(II), Ni(II), Pd(II), and Ag(I)—A Review

Abstract

: This review focuses on some interesting and recent applications of transition metals towards the complexation of thiosemicarbazides, thiocarbohydrazides, and their corresponding carbazones. We started the review with a description of the chosen five metals, including Cu[Cu(I), Cu(II], Co(II), Ni(II), Pd(II), and Ag(I) and their electronic configurations. The stability of the assigned complexes was also discussed. We shed light on different routes describing the synthesis of these ligands. We also reported on different examples of the synthesis of Cu(I), Cu(II), Co(II), Ni(II), Ag(I), and Pd(II) of thiosemicarbazide and thiocarbohydrazide complexes (until 2022). This review also deals with a summary of the fruitful use of metal complexes of thiosemicarbazones and thiocarbazones ligands in the field of catalysis. Finally, this recent review focuses on the applications of these complexes related to their biological importance.

Synthesis, crystal structure and Hirshfeld analysis of trans-bis(2-{1-[(6R,S)-3,5,5,6,8,8-hexamethyl-5,6,7,8-tetrahydronaphthalen-2-yl]ethylidene}-N-methylhydrazinecarbothioamidato-κ2 N 2,S)palladium(II) ethanol monosolvate

“…Furthermore, in the field of materials science, a palladium(II) coordination compound, with the 4-{bis[4-(p-methoxyphenyl)thiosemicarbazone]}-2,3-butane derivative, has found application in electrocatalytic hydrogen production (Straistari et al, 2018), which is an important topic for energy research today. Finally, bioinorganic chemistry is one of the most relevant approaches for thiosemicarbazone chemistry (Aly et al, 2023;Singh et al, 2023).…”

From waste to wealth: chelating polymeric membranes for precious palladium recovery from wastewater

“…The thiosemicarbazide group is considered a good chelation group since it has better coordination tendencies, forms more stable complexes, has better selectivity, and may form macrocyclic ligands. 37 PTSC's structural composition is presented in Scheme 1. Campbell and Tomic previously synthesized PTSC in 1962, and their pioneering work highlighted its capacity to form chemical complexes with various metal ions, including iron, nickel, and copper.…”

Copper(II) and copper(I) complexes with a bidentate hydrazinic dithiocarbazate: synthesis and crystal structures

“…Hard nitrogen and soft sulfur donor atoms are co-present in the structure of important multidentate ligands such as dithiocarbazates, thiosemicarbazones and bis-thiosemicarbazones. Given the presence of the N,S donor set, these ligands coordinate a wide range of transition and non-transition metal ions [21][22][23] , generating stable complexes with promising pharmacological properties including antifungal, antibacterial, and antitumor activities 7,[24][25][26][27][28][29][30][31][32][33] . Among these, copper(II) compounds appear to be promising candidates due to their cytotoxic activity against human cancer cell lines 2,6,7,28,31,[34][35][36][37][38] .…”