Transition Metal/Lewis Acid Co‐Catalyzed Ring‐Opening Reactions of Oxa/Azabenzonorbornadienes

Abstract

The transition metal catalyzed ring-opening reactions of oxa/ azabenzonorbornadienes have emerged as one of the important methods for the synthesis of structural framework of biological importance bearing multiple functional groups. The reactions are catalyzed by transition metals such as Pd, Ir, Rh, Cu, Co, Pt, Ru, etc. Pioneered by Lautens et. al, it was realized that Lewis acids (LA) can play an important role in the ring-opening reaction and hence enhance both the reaction yield and stereo/regioselectivity of the products. They act as an activator/co-catalyst in the ring-opening reaction. In this review, we present an overview of the transition metal/Lewis acid co-catalyzed ring-opening reactions of oxa/azabenzonorbornadienes with different nucleophiles leading to the formation of different ring-opening products.

Copper-Catalyzed Cycloaddition of Heterobicyclic Alkenes with Diaryl Disulfides to Synthesize Dihydrobenzo[b]thiophene Derivatives

“…Heterobicyclic alkenes with special structure are utilized as building blocks for the synthesis of complex molecules with defined stereochemical structure . Many researchers including us have done much work about the asymmetric ring-opening and addition reactions of heterobicyclic alkenes with multifarious nucleophiles to form C–X bonds (X = C, N, O, etc.)…”