Transition Metal Promoted Synthesis of Isoindoline Derivatives

C(3)-Aryl isoindolinones: a PTSA-mediated access and improved synthesis of (±)-nuevamine

“…Over the past decade, several approaches have been made for the synthesis of C(3)-substituted isoindolinones. 19 In this pursuit, the generation and quenching of N -acyliminium ions at the α-position in the isoindolinone with a nucleophile are highly attractive. 20 The N -acyliminium ions can be generated readily from C(3)-hydroxy isoindolinones, which can be prepared easily in near-quantitative yields, by the partial reduction of phthalimides.…”