Transition metallo-curcumin complexes: a new hope for endometriosis?

Singh, Apoorva; Ghosh, Pooja; Mukherjee, Shankar; Ojha, Atul Kumar; Hansda, Anita; Choudhury, Priyanka; Halder, S.C.; Sharma, Sunita; Mukherjee, Gayatri; Dasgupta, Swagata; Chaudhury, Koel

doi:10.1039/d2tb01651f

Cited by 5 publications

(5 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As shown in Fig. 7(c), with various concentrations of HGPF (up to 200 μg mL −1 ), the hemolysis rates were all below the negative reaction limit of 5%, 55 demonstrating no obvious hemolysis was caused by HGPF. Therefore, HGPF was considered to be hemocompatible and was regarded as bio-safe for the potential therapeutic procedure.…”

Section: Resultsmentioning

confidence: 84%

A porphyrin-MOF-based integrated nanozyme system for catalytic cascades and light-enhanced synergistic amplification of cellular oxidative stress

Wei

et al. 2023

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 84%

A porphyrin-MOF-based integrated nanozyme system for catalytic cascades and light-enhanced synergistic amplification of cellular oxidative stress

Wei

et al. 2023

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

“…The isolation protocol and subject selection for all the cell types used are described in detail in the Supporting Information Section DS3. The hESCs were also isolated by enzymatic digestion according to the protocol described elsewhere . The protocol is described in detail in section DS4, Supporting Information.…”

Section: Methodsmentioning

confidence: 99%

“…The hESCs were also isolated by enzymatic digestion according to the protocol described elsewhere. 41 The protocol is described in detail in section DS4, Supporting Information. All experiments were carried out with cells ≤ passage 5.…”

Section: Fabrication Of Hybrid Stent By Combining Electrospinning And...mentioning

confidence: 99%

Biodegradable Multi-layered Silk Fibroin-PCL Stent for the Management of Cervical Atresia: In Vitro Cytocompatibility and Extracellular Matrix Remodeling In Vivo

Ojha,

Rajasekaran,

Hansda

et al. 2023

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

Cervical atresia is a rare congenital Mullerian duct anomaly that manifests as the absence or deformed nonfunctional presence of the cervix. Herein, a multi-layered biodegradable stent is fabricated using a homogeneous blend of silk fibroin with polycaprolactone using hexafluoroisopropanol as a common solution. Briefly, a concentric cylinder of 3D honeycomb layer is sandwiched within electrospun sheets for fixing at the cervico-uterine junction to pave the way of cervical reconstruction. An average length of 40 mm with 3 mm diameter is fabricated for the hybrid stent design. SEM evidences an evenly distributed pore architecture of the electrospun layer, and mechanical characterization of stent reveals a tensile strength of 1.7 ± 0.2 MPa, with a Young's modulus of 5.9 ± 0.1 MPa. Physico-chemical characterization confirms the presence of silk fibroin and poly caprolactone within the engineered stent. Following 14 days of pepsin enzymatic degradation, 18% degradation and a contact angle measurement of 97°are observed. In vitro cytocompatibility studies are performed using site-specific primary human cervical squamous, columnar epithelial cells, and human endometrial stromal cells. The study demonstrates non-cytotoxic cells' viability (no significant toxicity), improved cell anchoring, adherence among the stent layers, and proliferation in the 3D microenvironment. Furthermore, in vivo subcutaneous studies in the rodent model indicate that the implanted stent undergoes constructive remodeling, neo-tissue creation, neo-vasculature formation, and re-epithelialization while maintaining patency for 2 months.

show abstract

“…First, the combined use of Cu and curcumin was investigated. Although the addition of Cu effectively enhanced the effects of curcumin, in this case, this trace metal should be considered as an effective carrier rather than an active substance [ 109 ]. On the other hand, it was found that pharmacological reduction of copper levels may result in stopping the growth of endometriotic lesions.…”

Section: The Role Of Selected Dietary Components In the Course Of End...mentioning

confidence: 99%

How Can Selected Dietary Ingredients Influence the Development and Progression of Endometriosis?

Abramiuk,

Mertowska,

Frankowska

et al. 2024

Nutrients

View full text Add to dashboard Cite

Endometriosis is a chronic, hormone-dependent disease characterized by the presence of endometrial tissue in ectopic locations. Since the treatment options for this disease are still limited, and the cure rate is unsatisfactory, the search for ways to treat symptoms and modify the course of the disease is of key importance in improving the quality of life of patients with endometriosis. So far, the literature has shown that nutrition can influence endometriosis through hormonal modification and altering the inflammatory or oxidative response. Since the importance of nutrition in this disease is still a subject of scientific research, we aimed to summarize the current knowledge on the role of dietary modifications in endometriosis. Our review showed that nutrients with anti-inflammatory and antioxidant properties, including most vitamins and several trace elements, may influence the pathogenesis of endometriosis and can be considered as the nutrients preventing the development of endometriosis. However, despite the many discoveries described in this review, further interdisciplinary research on this topic seems to be extremely important, as in the future, it may result in the development of personalized therapies supporting the treatment of endometriosis.

show abstract

Transition metallo-curcumin complexes: a new hope for endometriosis?

Abstract: The metallo-curcumin complexes, copper–curcumin and nickel–curcumin, are promising anti-endometriotic agents due to their high antioxidant activity, selective cytotoxicity and active transport mediated accumulation in endometriotic cells.

Cited by 5 publications

References 89 publications

A porphyrin-MOF-based integrated nanozyme system for catalytic cascades and light-enhanced synergistic amplification of cellular oxidative stress

A porphyrin-MOF-based integrated nanozyme system for catalytic cascades and light-enhanced synergistic amplification of cellular oxidative stress

Biodegradable Multi-layered Silk Fibroin-PCL Stent for the Management of Cervical Atresia: In Vitro Cytocompatibility and Extracellular Matrix Remodeling In Vivo

How Can Selected Dietary Ingredients Influence the Development and Progression of Endometriosis?

Contact Info

Product

Resources

About