Transition of Children with Perinatally Acquired HIV-Infection into Adulthood: Social Outcome and Quality of Life

Sanjeeva, G N; Sahana, M. S.; Pavithra, H. B.; Swamy, V. H. T.; Srirama, B. R.; Kumar, Deepak; Hande, Lalitha; Mothi, S. N.

doi:10.1007/s12098-018-2816-8

Cited by 7 publications

(3 citation statements)

References 19 publications

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“…Widespread access to antiretroviral therapy has led many perinatally HIV-infected children to reach adolescence and adulthood [ 9 , 10 ]. They become sexually active and make decisions about their reproductive health.…”

Section: Introductionmentioning

confidence: 99%

Long‐Term Administration of Abacavir and Etravirine Impairs Semen Quality and Alters Redox System and Bone Metabolism in Growing Male Wistar Rats

Matuszewska

Nowak

Niżański

et al. 2021

Oxidative Medicine and Cellular Longevity

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Highly active antiretroviral therapy (HAART) is used in HIV-infected patients. Alongside the prolongation of patients’ life, adverse side effects associated with long-term therapy are becoming an increasing problem. Therefore, optimizing of HAART is extremely important. The study is aimed at evaluating the toxicity of abacavir and etravirine in monotherapy on the reproductive system, liver, kidneys, and bones in young, sexually mature, male rats. Thirty-six 8-week-old male Wistar rats randomized into three 12-animal groups received either normal saline (control), abacavir 60 mg/kg (AB group), or etravirine 40 mg/kg (ET group) once daily for 16 weeks. Semen morphology, oxide–redox state parameters (MDA, SOD, catalase, GPx, glutathione, GSH/GSSG ratio) in tissue homogenates (testes, liver, kidneys), and serum samples were studied. In bones, microcomputed tomography and a four-point bending test were performed. Total sperm count, sperm concentration, motility, and sperm morphology did not differ significantly in AB or ET groups compared to the control. In the flow cytometry of semen, an increased percentage of cells with denatured DNA was noticed for both tested drugs. However, no significant changes of oxide–redox state in testicular homogenates were found, except of increased SOD activity in the AB-receiving group. Additionally, ET significantly altered catalase and GPx in the liver and SOD activity in kidneys. Abacavir decreased catalase in the liver and GSH levels in kidneys. AB caused significant changes to bone microarchitecture (bone volume fraction, trabecular number, connectivity density, total porosity) and increased Young’s modulus. Etravirine had a greater impact on macrometric parameters of bones (tibial index, mid-tibial diameter, femur length). After 4 weeks in the ET group, a lower 1,25-dihydroxyvitamin D3 serum concentration was found. The results showed that abacavir and etravirine disturb oxidative stress. An increase in the percentage of sperms with chromatin damage suggests decreased fertility in rats receiving the studied drugs. Both drugs affected bone formation in growing rats. Additionally, etravirine disturbed vitamin D metabolism.

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Section: Introductionmentioning

confidence: 99%

Long‐Term Administration of Abacavir and Etravirine Impairs Semen Quality and Alters Redox System and Bone Metabolism in Growing Male Wistar Rats

Matuszewska

Nowak

Niżański

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…With suppressive ART, health-related QOL has improved markedly; however, high rates of double orphanhood continue to impact adult life. For young adults LWPaHIV in India (mean age: 18.9), almost two thirds were double orphans, having further impacts on education, with 58% dropping out of school and from employment [ 43 ]. However, in the US, markers of resilience, including high school graduation, tertiary education and current employment, were comparable between young adults aged 19–27 LWPaHIV and HEU youth [ 44 ].…”

Section: Neurocognitive Mental Health and Quality Of Life Outcomes In...mentioning

confidence: 99%

Adults with Perinatally Acquired HIV; Emerging Clinical Outcomes and Data Gaps

Henderson,

Fidler,

Foster

2024

TropicalMed

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In resourced settings, adults living with perinatally acquired HIV are approaching the 5th decade of life. Their clinical and psychological outcomes highlight potential future issues for the much larger number of adolescents growing up with HIV in sub–Saharan Africa, and will inform the development of appropriate healthcare services. Lifelong exposure to HIV, and increasingly to antiretroviral therapy throughout growth and development, contrasts with adults acquiring HIV in later life. This review describes the clinical outcomes for adults living with perinatally acquired HIV including post transition mortality, morbidity and retention in care. Rates of viral suppression, drug resistance and immunological function are explored. Co-morbidities focus on metabolic, cardiovascular, respiratory and bone health with quality-of-life data including neurocognitive functioning and mental health. Sexual and reproductive health including vaccine-preventable disease and the prevention of onward transmission to partners and infants are considered. The data gaps and future research questions to optimise outcomes for this emerging adult cohort are highlighted.

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“…Por ello se rechaza la hipótesis nula y se acepta la hipótesis alternativa. Estos resultados coinciden con aquellos estudios que hablan que los problemas de salud mental (Sherbourne et al, 2000;Degroote et al, 2013;Ballester-Arnal et al, 2016;Catalan et al, 2017;Shrestha et al, 2017;Tran et al, 2018;Nyongesa et al, 2018;Gebremichael et al, 2018;Huang et al, 2018;Costa et al, 2019;Castro et al, 2019), el bajo nivel educativo (Campsmith et al, 2003;Blackstone et al, 2013;Miners et al, 2014;Gebremichael et al, 2018;Fuster-RuizdeApodaca et al, 2018a;Sanjeeva et al, 2019;Costa et al, 2019;Castro et al, 2019) y la edad avanzada (Campsmith et al, 2003;Miners et al, 2014;Huang et al, 2018;Fuster-RuizdeApodaca et al, 2018a;Castro et al, 2019) influyen en el menor nivel de CdV en las PVIH. Y también con aquellos estudios que hablan que el mayor nivel educativo es un factor protector de la CdV en las PVIH (Monteiro et al, 2016;Catalan et al, 2017).…”

Section: Discussionunclassified

El papel de las funciones ejecutivas en la calidad de vida en personas con VIH en situación de vulnerabilidad social

Marijuán¹

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Transition of Children with Perinatally Acquired HIV-Infection into Adulthood: Social Outcome and Quality of Life

Cited by 7 publications

References 19 publications

Long‐Term Administration of Abacavir and Etravirine Impairs Semen Quality and Alters Redox System and Bone Metabolism in Growing Male Wistar Rats

Long‐Term Administration of Abacavir and Etravirine Impairs Semen Quality and Alters Redox System and Bone Metabolism in Growing Male Wistar Rats

Adults with Perinatally Acquired HIV; Emerging Clinical Outcomes and Data Gaps

El papel de las funciones ejecutivas en la calidad de vida en personas con VIH en situación de vulnerabilidad social

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