Transition of Essential Thrombocythemia to Megakaryoblastic Leukemia after Long-Term Therapy with Sequential Busulfan, Pipobroman and Hydroxyurea

Essential thrombocytemia progressing to Ph+ chronic myeloid leukemia with megakaryoblastic blasts, following anagrelide withdrawal

“…She is currently receiving imatinib at a dose of 200 mg OD orally, and her creatinine levels have returned to normal. Previous studies showing ET progression towards leukemia with t (9;22) and megakaryoblastic M7 appearances have already been reported in the literature [2][3][4]. This case further highlights a possible link between ANA and leukemia.…”