This study aims to estimate job satisfaction levels in graduated of dental school of Autonomous University of Guerrero, México, and determine which factors influence such satisfaction levels. A cross-sectional study was carried out in 144 dentists graduated from the dental school of Autonomous University of Guerrero through a validated survey. Logistic regression analysis was performed to obtain OR, p-value and confidence intervals (95% CI) in the STATA13 statistical program. The overall percentage of job satisfaction was 92%, while the variables that explained the model were, the role of the dentist (Owner or employed) (OR = 2.2 , p = 0.03 95% CI 1.1-4.4), and the level of satisfaction of the knowledge acquired within their academic dental school training (OR = 19.2, p = 0.00 95%CI 3.1-118). The professional satisfaction of a dentist is of great importance, because it impacts their performance at work, and is closely related to overall satisfaction of life, since both contribute reciprocally to the happiness of a person, as well as the general welfare in the community.