As a double border area of eastern and central areas, anhui "duplicity", facing the national development strategy of multiple stacking, cultural historical heritage deep, science and technology innovation ability for many years in the country the first phalanx, transportation network access, the ecological environment is good, in the development of Yangtze river delta integration has obvious comparative advantage. Therefore, Anhui should take the initiative in the integration of the Yangtze River Delta and the high-quality development of the central region. The use and promotion of artificial intelligence technology is a profound educational change in innovation and entrepreneurship education, which better meets the requirements of the combination of theory and practice in innovation and entrepreneurship education, and has broad development prospects and great application value. This paper establishes a complete set of application modeling system of entrepreneurship training based on artificial intelligence technology. The experimental results show that the application model of entrepreneurial cultivation has good prediction performance, and the evaluation model can provide accurate information and decision support, which has a good application prospect.