2001
DOI: 10.1055/s-2001-15486
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Transitional Cell Carcinoma of the Urinary Bladder Following Exposure to Cyclophosphamide in Childhood

Abstract: With the increasing survival of children with malignancies, the long-term effects of chemotherapies are now becoming important and one of these dreadful long-term complications is the development of a second malignancy. Described here is a case of transitional cell carcinoma of the bladder developing 8 years following exposure to cyclophosphamide for the treatment of embryonal rhabdomyosarcoma.

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Cited by 13 publications
(9 citation statements)
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“…When additional data from 20 case reports were included for group 1 patients, few (2%) grade 3 tumors were reported but overall still remained predominantly low grade. [15][16][17][18][19][20][21][22][23][24][48][49][50][51][52][53][54][55][56][57] In contrast, Migaldi et al 5 reported in elderly patients (mean, 70.2±8.4 y) incidences for grades 1, 2, and 3 bladder urothelial carcinomas of 13%, 51%, and 36%, respectively. This distribution in elderly patients had fewer grade 1 and as expected had more grade 3/or high-grade tumors when compared with patients in their fourth decades of life only.…”
Section: Patient Characteristics and Clinical Featuresmentioning
confidence: 99%
See 1 more Smart Citation
“…When additional data from 20 case reports were included for group 1 patients, few (2%) grade 3 tumors were reported but overall still remained predominantly low grade. [15][16][17][18][19][20][21][22][23][24][48][49][50][51][52][53][54][55][56][57] In contrast, Migaldi et al 5 reported in elderly patients (mean, 70.2±8.4 y) incidences for grades 1, 2, and 3 bladder urothelial carcinomas of 13%, 51%, and 36%, respectively. This distribution in elderly patients had fewer grade 1 and as expected had more grade 3/or high-grade tumors when compared with patients in their fourth decades of life only.…”
Section: Patient Characteristics and Clinical Featuresmentioning
confidence: 99%
“…I t is estimated that there will be 70,530 cases of urinary bladder urothelial cancer (52,760 in men and 17,770 in women) in the United States in 2010, and it will remain the fourth most common type of cancer in men. 1 Bladder urothelial carcinoma is typically a disease of older individuals and the majority of patients are above 60 years of age at the time of diagnosis.…”
mentioning
confidence: 99%
“…Tumours of the lower urinary tract in children are usually mesodermal in origin. Bladder tumours of the epithelial origin are uncommon in children and extremely rare in children less than 10 years of age [1][2][3][4][5][6][7][8][9]. We wish to report two cases which initially presented with gross haematuria and features suggestive of urinary tract infection.…”
Section: Introductionmentioning
confidence: 99%
“…Alkylating chemothera peutic agents such as cyclophosphamide can adversely affect bladder function, and cyclophosphamide is well known to cause haemorrhagic cystitis as well as poten tially leading to transitional cell carcinoma. 33 Longterm bladder fibrosis and contracture has been reported in patients previously treated for haemorrhagic cystitis caused by cyclophosphamide. 34 Impairment of bladder function is of particular concern following radiation therapy, after which <50% of children will have a normally functioning bladder; 35 urodynamic evaluation of bladder function after multi modal treatment of pelvic rhabdomyosarcoma has found either reduced functional bladder capacity or abnormal voiding patterns in 64% of children examined.…”
Section: Genitourinary Late Effectsmentioning
confidence: 98%