Transitional changes in arachidonic acid metabolism by bovine embryos at different developmental stages

Hwang, Daniel; Pool, S.H.; Rorie, R.W.; Boudreau, Mary D.; Godke, R.A.

doi:10.1016/0090-6980(88)90130-x

Cited by 30 publications

(14 citation statements)

References 36 publications

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“…Although a direct effect of early trophoblast on endometrial FA has not been shown, the close contact of the trophoblast and endometrial surface (Wathes and Wooding, 1980;Simon et al, 2000) may facilitate such as effect. This mechanism may result in changes in the endometrial FA, such as the reduction of C20:1 and C20:2 in pregnant endometrial tissue, to facilitate the synthesis of prostaglandins and eicosanoids by the trophoblast (Hwang et al, 1988;Lewis, 1989). The implications of these opposing changes in arachidonic acid precursor FA (upregulation of C20:3n-6 and downregulation of C20:1 and C20:2) in the endometrial tissues of pregnant cows are not clear.…”

Section: Reproductive Statusmentioning

confidence: 99%

Genetic strain and reproductive status affect endometrial fatty acid concentrations

Meier

Peterson

Mitchell

et al. 2009

Journal of Dairy Science

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Poor reproductive performance limits cow longevity in seasonal, pasture-based dairy systems. Few differences in ovarian dynamics have been reported in different strains of Holstein-Friesian cows, implying that the uterine environment may be a key component determining reproductive success. To test the hypothesis that the uterine environment differs among genetic strains of the Holstein-Friesian cow, endometrial fatty acids (FA) were analyzed from New Zealand (NZ), and North American (NA) Holstein-Friesian cows. The effect of reproductive status was also investigated, with cows from both Holstein-Friesian strains slaughtered on either d 17 of the estrous cycle (termed cyclic) or d 17 of pregnancy (after embryo transfer; termed pregnant). Endometrial tissues were collected from 22 cows (NZ pregnant, n = 6; NZ cyclic, n = 4; NA pregnant, n = 6; NA cyclic, n = 6), and FA composition was analyzed. Daily plasma progesterone concentrations, milk production, milk FA composition, body weight, and body condition score were determined. Milk yield (4% fat-corrected milk) was similar for the NZ (28.5 kg/d) and NA (29.3 kg/d; SE 2.07 kg/d) cows, but NZ cows had a greater mean milk fat percentage. Mean plasma progesterone concentrations were significantly greater in NZ cows. Plasma progesterone concentrations were similar in the pregnant and cyclic groups. Mean length of the trophoblast recovered from the pregnant cows (NZ: 20.8 +/- 2.84 cm; NA: 27.9 +/- 10.23 cm) was not affected by genetic strain. Endometrial tissues from NZ cows contained greater concentrations of C17:0, C20:3n-3, and total polyunsaturated FA. The endometria from pregnant cows contained greater concentrations of C17:0, C20:2, and C20:3n-6, and less C20:1, C20:2, C20:5n-3. The observed changes in endometrial FA between Holstein-Friesian cows of different genetic origins or reproductive states may reflect differences in endometrial function and may affect reproductive function.

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Section: Reproductive Statusmentioning

confidence: 99%

Genetic strain and reproductive status affect endometrial fatty acid concentrations

Meier

Peterson

Mitchell

et al. 2009

Journal of Dairy Science

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“…Embryos also secrete prostaglandins which may contribute to pregnancy maintenance (Lewis et al, 1982;Hyland et al, 1982;Hwang et al, 1988). Embryos of sheep and cattle secrete luteo¬ trophic factors which stimulate progesterone production by luteal cells (Hickey & Hansel, 1987) and prevent PGF-2a-induced regression of the CL (Vallet et al, 1988).…”

Section: Introductionmentioning

confidence: 99%

Prostaglandin production by horse embryos and the effect of co-culture of embryos with endometrium from pregnant mares

Watson

Sertich²

1989

Reproduction

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Summary. Embryos, endometrial biopsies, and uterine lavage fluid were collected from pregnant and non-pregnant mares 14 days after ovulation. Embryos were cultured for 20\m=.\5h with and without endometrial tissue from pregnant mares, and endometrial tissue was cultured alone. Endometrial content of PGF tended to be higher (P = 0\m=.\06) in non-pregnant than in pregnant mares, but the amount of PGF released from tissue during culture was similar for pregnant and non-pregnant mares. Lavage fluid from non-pregnant mares also tended (P= 0\m=.\08) to contain higher concentrations of PGF. Co\ x=req-\ incubation of embryos with endometrium from pregnant mares significantly (P = 0\m=.\01) lowered concentrations of PGF in medium. Tissue concentrations and release of PGE-2 and 6-keto-PGF-1\g=a\were similar in endometrial samples from pregnant and non\x=req-\ pregnant mares and prostaglandin production was unaffected by the presence of an embryo during incubation. Horse embryos released all three prostaglandins during a 20\m=.\5-hincubation.

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“…Since that time many investigators have confirmed this observation and enlarged the original findings to include blastocysts of different ages (Dey et ai, 1980;Sharma, 1980;Pakrasi & Dey, 1982; Racowsky & Biggers, 1983;Harper et al, 1983;Kasamo, 1985;Kasamo et al, 1986), and of other species (Shemesh et ai, 1979;Marcus, 1981;Lewis et ai, 1982;Hyland et ai, 1982;Davis et ai, 1983;Hwang et al, 1988). Many of these studies relied on radioimmuno-assay of PGs released into the medium during in-vitro culture or of PGs found in the blastocyst itself.…”

Section: Introductionmentioning

confidence: 82%

Prostaglandin synthesis by Day-6 rabbit blastocysts in vitro

Harper

Jones²,

Norris³

et al. 1989

Reproduction

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Transitional changes in arachidonic acid metabolism by bovine embryos at different developmental stages

Cited by 30 publications

References 36 publications

Genetic strain and reproductive status affect endometrial fatty acid concentrations

Genetic strain and reproductive status affect endometrial fatty acid concentrations

Prostaglandin production by horse embryos and the effect of co-culture of embryos with endometrium from pregnant mares

Prostaglandin synthesis by Day-6 rabbit blastocysts in vitro

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